Identification of residues linked to the slow-->fast transition of thrombin.
about
Unexpected crucial role of residue 225 in serine proteasesImportant role of the cys-191 cys-220 disulfide bond in thrombin function and allosteryCrystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of ActivationRole of P225 and the C136-C201 disulfide bond in tissue plasminogen activator.How Na+ activates thrombin--a review of the functional and structural data.Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases.Histone H4 promotes prothrombin autoactivation.An extensive interaction interface between thrombin and factor V is required for factor V activation.Localization of phosphatidylserine binding sites to structural domains of factor Xa.Allosteric effects potentiating the release of the second fibrinopeptide A from fibrinogen by thrombin.The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.
P2860
Q27617423-9B600D38-E9BD-4396-B8FD-F9FCC1D526E8Q27646778-9C38C018-3314-4862-B4AD-87F9E5753656Q27678654-FCE75152-5CC3-4C84-BDDE-42F5D842357EQ33177672-12BBBFBC-19D7-4CCE-84CA-6B103F2576F2Q33382168-0342B008-CAB9-4738-A28A-DE7D34A9CC1BQ37289290-0A3C0060-14B9-4DB1-93C4-6EBE77474422Q37388786-F7662CAE-2AE5-40AB-99AE-8609CF19183FQ43581648-ED1C0BBA-B3B0-428B-BFF9-7FAD3549AC6EQ43798546-09CE5B88-E65F-4740-ABA6-0A1BDF5BC66BQ43916129-1B69F4AB-38F2-4C15-B80E-80A2BB315AACQ53626760-2A965201-AAC8-43B2-86E8-6A8C8791E2A0
P2860
Identification of residues linked to the slow-->fast transition of thrombin.
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification of residues linked to the slow-->fast transition of thrombin.
@ast
Identification of residues linked to the slow-->fast transition of thrombin.
@en
type
label
Identification of residues linked to the slow-->fast transition of thrombin.
@ast
Identification of residues linked to the slow-->fast transition of thrombin.
@en
prefLabel
Identification of residues linked to the slow-->fast transition of thrombin.
@ast
Identification of residues linked to the slow-->fast transition of thrombin.
@en
P2093
P2860
P356
P1476
Identification of residues linked to the slow-->fast transition of thrombin.
@en
P2093
P2860
P304
11185-11189
P356
10.1073/PNAS.92.24.11185
P407
P577
1995-11-01T00:00:00Z