An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
about
Crystal structure of the anticoagulant slow form of thrombinStructural basis of Na+ activation mimicry in murine thrombinImportant role of the cys-191 cys-220 disulfide bond in thrombin function and allosteryStructural identification of the pathway of long-range communication in an allosteric enzymeNa+ binding to meizothrombin desF1Stabilization of the E* Form Turns Thrombin into an AnticoagulantMutant N143P Reveals How Na+ Activates ThrombinRigidification of the autolysis loop enhances Na+ binding to thrombinExposure of R169 controls protein C activation and autoactivationPreparation of anhydrothrombin and characterization of its interaction with natural thrombin substratesDynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by ThrombinProton bridging in the interactions of thrombin with hirudin and its mimics.Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator.How Na+ activates thrombin--a review of the functional and structural data.Structure-based predictive models for allosteric hot spots.Proton bridging in the interactions of thrombin with small inhibitorsIdentification of residues linked to the slow-->fast transition of thrombin.Theory of allosteric effects in serine proteases.On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel.Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Redesigning allosteric activation in an enzyme.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Role of Na+ and K+ in enzyme function.How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of ProthrombinThrombin.Exosites in the substrate specificity of blood coagulation reactions.Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases.Mutagenesis studies toward understanding allostery in thrombin.Looking at the proteases from a simple perspective.Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis.Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C.Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site.Crystal structure of wild-type human thrombin in the Na+-free state.Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains.PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins.Heparin enhances the catalytic activity of des-ETW-thrombin.Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin.Prothrombin gene G20210A mutation in acute deep venous thrombosis patients with poor response to warfarin therapy
P2860
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P2860
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@ast
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@en
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@nl
type
label
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@ast
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@en
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@nl
prefLabel
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@ast
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@en
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@nl
P2093
P2860
P356
P1476
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.13.5977
P407
P577
1995-06-01T00:00:00Z