The presenilins in Alzheimer's disease--proteolysis holds the key.
about
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationThe gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleusPAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinDifferential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismRhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signalingAATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathwayAutosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor proteinBinding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavageInteractome mapping suggests new mechanistic details underlying Alzheimer's diseaseThe gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalingPresenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Signaling effect of amyloid-beta(42) on the processing of AbetaPPDeletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseCanonical and Non-canonical Reelin SignalingTrafficking regulation of proteins in Alzheimer's diseaseAutoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processingAPP processing in Alzheimer's diseaseProcessing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcriptionStatins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionConvergence of Wnt, beta-catenin, and cadherin pathwaysEndocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriersSelection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation.An in vivo assay for the identification of target proteases which cleave membrane-associated substrates.Protease specificity determination by using cellular libraries of peptide substrates (CLiPS).Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).Teneurin-1 is expressed in interconnected regions of the developing brain and is processed in vivoPresenilin-dependent gamma-secretase activity modulates thymocyte development.Implications of non-canonical G-protein signaling for the immune systemBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseBrain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.PABMB Lecture. Protein dynamics, folding and misfolding: from basic physical chemistry to human conformational diseases.Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment.Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects.Alzheimer's disease beta-amyloid peptides are released in association with exosomes.Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradationA screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.
P2860
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P2860
The presenilins in Alzheimer's disease--proteolysis holds the key.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The presenilins in Alzheimer's disease--proteolysis holds the key.
@ast
The presenilins in Alzheimer's disease--proteolysis holds the key.
@en
type
label
The presenilins in Alzheimer's disease--proteolysis holds the key.
@ast
The presenilins in Alzheimer's disease--proteolysis holds the key.
@en
prefLabel
The presenilins in Alzheimer's disease--proteolysis holds the key.
@ast
The presenilins in Alzheimer's disease--proteolysis holds the key.
@en
P1433
P1476
The presenilins in Alzheimer's disease--proteolysis holds the key.
@en
P2093
De Strooper B
P304
P356
10.1126/SCIENCE.286.5441.916
P407
P577
1999-10-01T00:00:00Z