Presenilin-dependent gamma-secretase activity modulates thymocyte development. - Wikidata - awgldk - TriplyDB

Presenilin-dependent gamma-secretase activity modulates thymocyte development.

Presenilin-dependent gamma-secretase activity modulates thymocyte development.

http://www.wikidata.org/entity/Q33930862

about

Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation Notch signaling in CD4 and CD8 T cell development In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease Presenilins regulate alphabeta T cell development by modulating TCR signaling Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.E proteins and the regulation of early lymphocyte development The γ-secretase complex: from structure to function.The role of Notch signaling during hematopoietic lineage commitment.Alzheimer's disease: beta-Amyloid protein and tau.A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.Amyloid, presenilins, and Alzheimer's disease.Aspartic proteases involved in Alzheimer's disease.An overview of notch signaling in adult tissue renewal and maintenance.Notch regulates cytolytic effector function in CD8+ T cells.Wheat germ agglutinin enhanced cerebral uptake of anti-Aβ antibody after intranasal administration in 5XFAD mice Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.TCR and Notch signaling in CD4 and CD8 T-cell development.Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells Notch signaling in T-cell acute lymphoblastic leukemia.Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.A survey of peptides with effective therapeutic potential in Alzheimer's disease rodent models or in human clinical studies.Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

P2860

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P2860

Presenilin-dependent gamma-secretase activity modulates thymocyte development.

http://www.wikidata.org/entity/Q33930862

description

2001 nî lūn-bûn

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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2001 թվականի հուլիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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prefLabel

Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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Proceedings of the National Academy of Sciences of the United States of America

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Presenilin-dependent gamma-secretase activity modulates thymocyte development.

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Doerfler P

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Perlmutter RM

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Shearman MS

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P2860

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact

The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

Notch signaling: cell fate control and signal integration in development

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Presenilin is required for activity and nuclear access of Notch in Drosophila

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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