From induced fit to conformational selection: a continuum of binding mechanism controlled by the timescale of conformational transitions
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Many local motions cooperate to produce the adenylate kinase conformational transitionInsights into Protein-Ligand Interactions: Mechanisms, Models, and MethodsPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthaseA role for both conformational selection and induced fit in ligand binding by the LAO proteinThe role of flexibility and conformational selection in the binding promiscuity of PDZ domainsElectrostatically accelerated encounter and folding for facile recognition of intrinsically disordered proteinsQuantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysisEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesResolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains.Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Dynamic New World: Refining Our View of Protein Structure, Function and EvolutionDiffusion and association processes in biological systems: theory, computation and experiment.Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.In silico elucidation of the recognition dynamics of ubiquitinBoth protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fitKinetic rate constant prediction supports the conformational selection mechanism of protein binding.Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Exploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.Taking Ockham's razor to enzyme dynamics and catalysis.Ubiquitin dynamics in complexes reveal molecular recognition mechanisms beyond induced fit and conformational selection.Theory and simulation on the kinetics of protein-ligand binding coupled to conformational change.Side-chain conformational changes upon Protein-Protein AssociationBeyond the random coil: stochastic conformational switching in intrinsically disordered proteins.Rapid search for specific sites on DNA through conformational switch of nonspecifically bound proteins.Dynamic conformational change regulates the protein-DNA recognition: an investigation on binding of a Y-family polymerase to its target DNA.The intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topology.Effect of Src kinase phosphorylation on disordered C-terminal domain of N-methyl-D-aspartic acid (NMDA) receptor subunit GluN2B protein.Theory and simulation of diffusion-influenced, stochastically gated ligand binding to buried sites.TBI server: a web server for predicting ion effects in RNA folding.Markov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement.Allostery through the computational microscope: cAMP activation of a canonical signalling domainElectrostatically accelerated coupled binding and folding of intrinsically disordered proteinsBDflex: a method for efficient treatment of molecular flexibility in calculating protein-ligand binding rate constants from brownian dynamics simulationsConformational plasticity of an enzyme during catalysis: intricate coupling between cyclophilin A dynamics and substrate turnover.Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.Rational prediction with molecular dynamics for hit identificationComputational models of protein kinematics and dynamics: beyond simulation.
P2860
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P2860
From induced fit to conformational selection: a continuum of binding mechanism controlled by the timescale of conformational transitions
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
From induced fit to conformati ...... of conformational transitions
@ast
From induced fit to conformati ...... of conformational transitions
@en
type
label
From induced fit to conformati ...... of conformational transitions
@ast
From induced fit to conformati ...... of conformational transitions
@en
prefLabel
From induced fit to conformati ...... of conformational transitions
@ast
From induced fit to conformati ...... of conformational transitions
@en
P2860
P1433
P1476
From induced fit to conformati ...... of conformational transitions
@en
P2093
Huan-Xiang Zhou
P2860
P356
10.1016/J.BPJ.2009.11.029
P407
P577
2010-03-01T00:00:00Z