Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
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Crystal structure, SAXS and kinetic mechanism of hyperthermophilic ADP-dependent glucokinase from Thermococcus litoralis reveal a conserved mechanism for catalysisInsights into Coupled Folding and Binding Mechanisms from Kinetic StudiesInsights into Protein-Ligand Interactions: Mechanisms, Models, and MethodsConformational selection in protein binding and functionAutoactivation of Thrombin PrecursorsEssential role of conformational selection in ligand bindingLigand concentration regulates the pathways of coupled protein folding and binding.Molecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic TriadLoop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in ThrombinBinding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and ExperimentKeep on moving: discovering and perturbing the conformational dynamics of enzymesDynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by ThrombinHow to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation RatesDisordered proteinaceous machinesMg2+Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational SelectionBuilding a virtual ligand screening pipeline using free software: a surveyAn Asymmetric Conformational Change in LacY.Why Ser and not Thr brokers catalysis in the trypsin foldKinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.Identification of two-step chemical mechanisms using small temperature oscillations and a single tagged species.Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.Ezrin interacts with S100A4 via both its N- and C-terminal domains.Drug design from the cryptic inhibitor envelope.Ligand binding to anion-binding exosites regulates conformational properties of thrombin.Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitopeSubstrate protein folds while it is bound to the ATP-independent chaperone SpyA novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes.S-nitrosation of glutathione transferase p1-1 is controlled by the conformation of a dynamic active site helix.Enzymatic detoxication, conformational selection, and the role of molten globule active sites.Induced fit substrate binding to an archeal glutamate transporter homologueWhat Mutagenesis Can and Cannot Reveal About Allostery.Conformational selection is a dominant mechanism of ligand bindingHistone H4 promotes prothrombin autoactivation.Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement.Flexibility and reactivity in promiscuous enzymes.Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding.Probing allosteric mechanisms using native mass spectrometry.Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.Estimation of kinetic and thermodynamic ligand-binding parameters using computational strategies.Protein dynamics and function from solution state NMR spectroscopy.
P2860
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P2860
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@ast
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@en
type
label
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@ast
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@en
prefLabel
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@ast
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@en
P2860
P356
P1433
P1476
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.
@en
P2093
Austin D Vogt
Enrico Di Cera
P2860
P304
P356
10.1021/BI3006913
P407
P577
2012-07-16T00:00:00Z