Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. - Wikidata - awgldk - TriplyDB

Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.

Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.

http://www.wikidata.org/entity/Q33777882

about

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain Cargos and genes: insights into vesicular transport from inherited human disease Mechanisms of action of glucagon-like peptide 1 in the pancreas Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells Neurexin-1α contributes to insulin-containing secretory granule docking Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila Small G proteins in islet beta-cell function.Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET.Essential role of the small GTPase Ran in postnatal pancreatic islet development.ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.The GTPase Rab37 Participates in the Control of Insulin Exocytosis.Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion.Rab27a: a new face in beta cell metabolism-secretion coupling.Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.Rab GTPases implicated in inherited and acquired disorders.Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane.PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.Rab27b regulates mast cell granule dynamics and secretion.Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats Granuphilin molecularly docks insulin granules to the fusion machinery.Lysosomal integral membrane protein Sidt2 plays a vital role in insulin secretion.Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4.Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin.Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms Small G proteins as key regulators of pancreatic digestive enzyme secretion.Newcomer insulin secretory granules as a highly calcium-sensitive pool Interleukin-1 signaling contributes to acute islet compensation Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion.IG20/MADD plays a critical role in glucose-induced insulin secretion.

P2860

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P2860

Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.

http://www.wikidata.org/entity/Q33777882

description

2005 nî lūn-bûn

@nan

2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@ast

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@en

type

label

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@ast

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@en

prefLabel

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@ast

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@en

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P2860

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P1433

Journal of Clinical Investigation

P1476

Rab27a mediates the tight dock ...... ne during glucose stimulation.

@en

P2093

Haruo Kasai

http://www.w3.org/2001/XMLSchema#string

Hiroshi Gomi

http://www.w3.org/2001/XMLSchema#string

Kazuo Kasai

http://www.w3.org/2001/XMLSchema#string

Mica Ohara-Imaizumi

http://www.w3.org/2001/XMLSchema#string

Noriko Takahashi

http://www.w3.org/2001/XMLSchema#string

Shengli Zhao

http://www.w3.org/2001/XMLSchema#string

Shin Mizutani

http://www.w3.org/2001/XMLSchema#string

Shinya Nagamatsu

http://www.w3.org/2001/XMLSchema#string

Tetsuro Izumi

http://www.w3.org/2001/XMLSchema#string

Toshiteru Kikuta

http://www.w3.org/2001/XMLSchema#string

P2860

Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain

Identification of an organelle receptor for myosin-Va

Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells

A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

P304

388-396

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scholarly article

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10.1172/JCI22955

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P407

P433

2

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P478

115

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2005-02-01T00:00:00Z

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15690086

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P932

546426

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