The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain
about
sameAs
MyRIP anchors protein kinase A to the exocyst complexSecretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesA family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportConstitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in plateletsScreening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activityMyosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cellsSlp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapseGriscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cellsA coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphataseGene expression signature of estrogen receptor alpha status in breast cancerRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsGenome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transportDistinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cellsIdentification of EPI64 as a GTPase-activating protein specific for Rab27AVarp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytesThe recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome traffickingRabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cellsInsulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4CThe C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cellsSlac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actinMyosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cellsThe role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cellsRole of Rab GTPases in membrane traffic and cell physiologyThe ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.A general role for Rab27a in secretory cells.The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform.Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells.Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome.Rab GTPases and myosin motors in organelle motility.
P2860
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
P248
Q24293041-6384ED14-85B1-4692-8889-839368CBE1D2Q24293621-35A5627C-BEFE-40C7-9077-5C70B9D27F9DQ24294793-BC1D8E40-2C7E-42BC-8D09-DF0498E79734Q24295585-9C40B07B-AE0E-4EA0-9F4F-A5AE69EACF40Q24298411-0A46BC74-9B46-44EA-8C60-0EF08F68549BQ24300416-E6634969-B387-406D-B7B2-B99D6FF6ECE0Q24304047-5CF8FD1B-1705-49DD-ADC9-BC135ED504F4Q24312915-68BE297C-8A77-491B-A10C-017AA8661CB7Q24313435-6F9CC303-271A-4484-A41B-8652BEEA6770Q24315756-684E6EFE-D2D2-4F67-8495-13E90ACB73F3Q24318611-79138C81-8869-43B5-8C69-294231FD6BA3Q24537168-BE876321-D747-43DF-96C2-052F64E6F216Q24805289-E0EFF319-8AC3-4B55-8250-5F97C835EB77Q27012658-82E4DD58-C8BC-4CDF-B568-735DB57504E9Q27313513-CD54DE78-9C07-4B77-ADFD-F407F3A985FBQ28202672-389CF3EF-0C4B-40DD-A3D8-A31DDBFAF0D6Q28208436-9066F30C-1C45-4812-9190-CC01196657C9Q28210017-E4090AB0-74F2-4905-A73E-D58853194C26Q28259174-E97232A5-34A5-4269-8CFE-90D9939F6E3BQ28505813-4339473A-E535-4301-B693-FDEE1A72EBD9Q28507551-B225B2E1-362F-4BF4-BB34-EEE51D28F9DDQ28510077-734F2B5B-4EA2-44B4-AA83-4D18B3B510ADQ28511897-752B6609-2C90-4FE1-8CD6-76CB695465DCQ28565346-D0209BFF-943A-4846-899F-C1CD96408B24Q28584753-0DF0D481-614C-4BB6-B465-C64754447774Q28589310-30C97F7B-7026-4643-AC10-530828EF4FBFQ28594091-DE682FF9-C1F4-4C50-9A30-15C5EDE1EA4AQ29616548-791BCB45-9FD1-4883-80CB-47EBF5482516Q30479761-7499FA39-4E87-49FB-9C81-E6FAA08F5DF8Q30499499-4C82F27C-9F1B-480F-88C0-2EA7A6D06CC9Q31018337-8112E0B9-56B3-4E3F-AC4F-D6C779FC6293Q33294327-BBF9FF1C-9123-4D11-881A-C57AAFA5E12AQ33777882-80B87E21-D040-44B8-A616-BE586DDA5198Q33810384-CD5B37ED-6742-41C2-B9FA-02954566FC6FQ34047949-1A351F54-3653-43CA-B403-80E46A5196EBQ34144438-6D2DD146-10BD-477F-9769-A2CF567D9AE7Q34145357-624B33D0-0292-42D7-ACEA-D754DC8E7C6DQ34153990-19AABB48-AA84-49E0-A056-CFFD9DD43527Q34171093-153DBF53-058D-46C0-93AB-4E6C248CF4BAQ34317344-450C65DB-1394-4F8D-885F-CBEE6E849A7B
P2860
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain
description
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im März 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 15 March 2002)
@en
vedecký článok (publikovaný 2002/03/15)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/03/15)
@nl
наукова стаття, опублікована в березні 2002
@uk
name
The Slp homology domain of syn ...... a novel Rab27A binding domain
@ast
The Slp homology domain of syn ...... a novel Rab27A binding domain
@en
The Slp homology domain of syn ...... a novel Rab27A binding domain
@nl
type
label
The Slp homology domain of syn ...... a novel Rab27A binding domain
@ast
The Slp homology domain of syn ...... a novel Rab27A binding domain
@en
The Slp homology domain of syn ...... a novel Rab27A binding domain
@nl
prefLabel
The Slp homology domain of syn ...... a novel Rab27A binding domain
@ast
The Slp homology domain of syn ...... a novel Rab27A binding domain
@en
The Slp homology domain of syn ...... a novel Rab27A binding domain
@nl
P2093
P2860
P921
P3181
P356
P1476
The Slp homology domain of syn ...... a novel Rab27A binding domain
@en
P2093
Hiroyoshi Ariga
Mitsunori Fukuda
Taruho S Kuroda
P2860
P304
P3181
P356
10.1074/JBC.M112414200
P407
P577
2002-03-15T00:00:00Z