Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse
about
Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11New Insights into How Trafficking Regulates T Cell Receptor SignalingCytotoxic granule secretion by lymphocytes and its link to immune homeostasisLysosome-Related Effector Vesicles in T Lymphocytes and NK CellsRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsDistinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cellsMEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.Syntaxin binding mechanism and disease-causing mutations in Munc18-2Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.Involvement of HAb18G/CD147 in T cell activation and immunological synapse formation.Shouts, whispers and the kiss of death: directional secretion in T cellsHow B cells capture, process and present antigens: a crucial role for cell polarity.Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane.Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cellsSequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cellsHuman immunodeficiency syndromes affecting human natural killer cell cytolytic activity.Rab27a/Slp2-a complex is involved in Schwann cell myelination.Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.Inherited defects in lymphocyte cytotoxic activity.Molecular mechanisms of natural killer cell activation.Insights into NK cell biology from human genetics and disease associations.Rab27 effectors, pleiotropic regulators in secretory pathways.Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes.Activation of Lymphocyte Cytolytic Machinery: Where are We?Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes.Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.
P2860
18499e20882bc561d9b186359a30bb82b46a8bc22184815373436fd52eed53b55098afea34f6c39d42b0fbc74848639e3812f0893cdee65b5ac29b7572b227fb4bb98454ef51c1b1c58e51d460e1ad58b0b744f7b3488bc266bbdab896555c40991de2f3dbf8205d68865bf51ab22ad0f5182517b651f4fff0b5bc975d52b301d9e5b7f7c4371af8b4ba5d82feb2bed75a8096715fa534752cf30b8cef9d6119
P248
Q24321783-94D6823D-1FCB-4BA9-ABBE-5F3E91B8DE7DQ26742022-7939B238-F479-4CF2-95BE-8E3CF01EFE16Q26776499-192FFD1E-6CB9-4CAE-A377-7375FA3363A5Q26828461-2BC87AF4-8E09-4CEA-9BAD-47C83520867AQ27012658-AB53AD01-730B-4F04-B1F1-BDE829792D50Q27319800-576F5DB9-CA50-494C-9EFC-E7BA8B15A5AEQ27331832-D401FD78-FB68-424D-91E7-63CD2A7EF35DQ27680537-A25F3811-976A-41C2-A93F-D17A619195B8Q30514034-56A769FE-334F-4FF7-94BB-7D342E887C2DQ33524885-6A19CB44-CC30-429E-8821-6AF797452B52Q34001889-FFB79CFE-5BEF-43A8-BD11-BB6B6DD7BB29Q34353214-D3553460-81F6-445D-B42C-B43F5B79BDE0Q34407717-7CFBC157-4466-45F3-B4E7-FE639B0C401FQ35566581-33203EAB-9263-4077-B2A2-3D5E0CA6A742Q35793467-832D7202-1921-4254-BEB7-AE381D48142DQ36161700-80F8BF63-3145-49F8-99AA-EBA8F4138F01Q36208239-70B94D0E-62DB-494A-85A6-559E3EF369B6Q36896310-68C2B903-B778-4780-9D73-9AEC35A3B9A9Q37497535-11780D2C-40E5-4CCE-BED6-AECD5A539DE1Q37548388-D22C8207-5666-47D0-9AB2-3336ED899231Q37719014-0D10049C-092B-4EA2-A8F8-426381FE28F0Q37763991-9CAE8B1B-9883-424B-8D1D-440737691D78Q37860083-D6E3E756-4DF6-407B-89FB-5C2104C0EC19Q37923353-C2D3794F-319D-4097-95F0-66FD7CBD9365Q38107224-D721232B-E038-4BD6-9E6D-F04BD0724337Q38168511-03576507-D6A3-420C-9417-B28A3CAC2EC6Q38169149-2F544B34-2F22-4C0B-A02A-35E8A391653EQ39323149-A53028E4-8265-4EB3-B0C2-F8631851397DQ39645396-211F50FF-4DEC-4811-8B6C-BC623F02E180Q41973673-D183A7F5-9C2A-4229-9D7D-A4D9B27FE815Q42053980-50951B1C-9107-4EE7-BA7F-6179D160E81FQ42912317-1570AF5E-3F5B-425B-8345-CB9F2DD5FEF3
P2860
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@ast
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en-gb
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@nl
type
label
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@ast
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en-gb
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@nl
prefLabel
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@ast
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en-gb
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
Slp1 and Slp2-a localize to th ...... from the immunological synapse
@en
P2093
Alessandra Santoro
Chika Saegusa
Eiko Kanno
Giovanna Bossi
Maurizio Arico
Oliver Holt
Sarah Booth
P2860
P304
P3181
P356
10.1111/J.1600-0854.2008.00714.X
P407
P577
2008-04-01T00:00:00Z