Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
about
Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocketThe Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor.Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild typeIsolation of novel EGFR-specific VHH domains.The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradationImpaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.Using iTRAQ combined with tandem affinity purification to enhance low-abundance proteins associated with somatically mutated EGFR core complexes in lung cancer.Discovery of putative oocyte quality markers by comparative ExacTag proteomicsNexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.Efficient blockade of Akt signaling is a determinant factor to overcome resistance to matuzumab.Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation.Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosisKnockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis.c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations.Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling.Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins.Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels.Binding of CBL to ligand-responsive p-6Y-EGFR mutantsInefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
P2860
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P2860
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Epidermal growth factor recept ...... t are efficiently internalized
@ast
Epidermal growth factor recept ...... t are efficiently internalized
@en
type
label
Epidermal growth factor recept ...... t are efficiently internalized
@ast
Epidermal growth factor recept ...... t are efficiently internalized
@en
prefLabel
Epidermal growth factor recept ...... t are efficiently internalized
@ast
Epidermal growth factor recept ...... t are efficiently internalized
@en
P2093
P2860
P1433
P1476
Epidermal growth factor recept ...... t are efficiently internalized
@en
P2093
Adi F Gazdar
David Padrón
Jerry W Shay
John D Minna
Mitsuo Sato
P2860
P304
P356
10.1158/0008-5472.CAN-07-0484
P407
P50
P577
2007-08-01T00:00:00Z