Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).
about
Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoterHuman receptor activation by aroclor 1260, a polychlorinated biphenyl mixtureStructural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationA single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Activation of xenobiotic receptors: driving into the nucleus.Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducersCamptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptorModulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression.Cell-based systems to assess nuclear receptor activation and their use in drug development.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesCYP2B6: new insights into a historically overlooked cytochrome P450 isozymeModulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptorDifferential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineMulti-species analyses of direct activators of the constitutive androstane receptor.CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Small-molecule modulators of the constitutive androstane receptor.Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoformsThe orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Expression of human CAR splicing variants in BAC-transgenic miceNonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectivePharmacogenetics of the constitutive androstane receptor.Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathwaysDi(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analoguesOxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.The novel antibacterial compound walrycin A induces human PXR transcriptional activity
P2860
Q28386991-1395AE4F-D1D3-4220-B03A-DA6903248A43Q28394850-493C3037-A754-453E-89D9-E14032D437DFQ28538476-5378272C-408C-495C-B156-9FE45BE46068Q28554648-A9DAFB59-4976-4588-B06A-7D38EDBE7D16Q33574862-F57D76C6-0FC8-4487-80E5-863A3DC2CC18Q33606475-850B68DF-2E6C-4448-929A-8AD1C62A644CQ33742134-D5512E81-1DCD-4CE9-BBF4-0440A68AB2ECQ33881813-36468DBC-D8BA-44C1-9594-9FCBFAC90B1BQ34128854-54E47B97-669D-4440-8BB1-45928A44ADEEQ34526408-6DED10B7-E13F-4FF2-A438-96B3BD07A49AQ34553662-8AA08D1C-D88E-46CE-9E0A-D71520597115Q34625038-9EABD3D3-08FB-4F31-89D8-B751EDAF2E91Q34824471-3589596C-7519-4309-BF41-3CFEDA69731CQ34904938-A0AC97AA-45E7-4222-8BB8-0B0ACF673EDBQ35022586-8A284DC1-86E6-453E-85F1-6FD285987B90Q35111456-67CBB4FC-40DD-4C5C-BA27-210F77A3C82EQ35231096-9A80B756-DD32-4232-B42D-EAB6D36E13B1Q35531860-EF9E9C2D-C10C-4EEF-8599-377815433FD2Q35748820-33E24E8A-97D6-42DE-BCF6-BBAEC3961A86Q35759931-F4B7107D-A295-4022-AABB-28089D9E0EFAQ35776828-3E81CB92-EA8C-4430-84CC-D6454642E974Q35804712-30A3AB92-F7DC-4043-9076-0FAA840D4E2FQ36037547-4DE16E5F-4802-4DE9-9192-9ABF627EFB23Q36254041-EB67F3B2-374D-46B3-A49D-E912FB00AC46Q36335562-39AACD2F-2FAE-4AC4-891C-22C31FAE4DC7Q36561847-169EF19E-47D4-48F6-9856-2B6FA0EF74BFQ36620461-BF7D8328-397F-40FB-AA09-C60637AF1908Q36737004-60893517-AA79-47E3-8756-E38081E4DE48Q36925723-0D83BC04-581A-414D-BEEA-375FE3185557Q36931713-B033BA11-8D09-4FDA-8C3D-771713F562DAQ37043505-4EAE7AC8-2018-4BFE-957F-E9ECA628D961Q37113524-2666F0B8-4182-4A5A-949A-087711D6AB0DQ37168382-D9F53F8C-5CE7-4B3F-8E00-B530A648803DQ37311631-6E3CA49F-499F-4F56-813B-2292C594DBE1Q37327409-A04194AD-3257-49FB-9BC3-E62956D1E769Q37386327-FC2A033E-3F2A-471F-83AC-71FE8674DB35Q37553490-7FCF51F4-27A5-45BF-9CE0-DD230360A3B4Q37587873-49241202-1823-469A-BF7C-1FABF2577F2DQ38211210-C0BFFDFF-F572-494E-BE39-2969CCAE40EEQ38327914-6AEB2EF2-6DFF-4FB4-849F-A804915EE629
P2860
Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@ast
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@en
type
label
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@ast
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@en
prefLabel
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@ast
Retinoid X receptor-alpha-depe ...... e androstane receptor (NR1I3).
@en
P2093
P2860
P356
P1476
Retinoid X receptor-alpha-depe ...... ve androstane receptor (NR1I3)
@en
P2093
Curtis J Omiecinski
Matthew A Stoner
Scott S Auerbach
P2860
P304
P356
10.1124/MOL.105.013417
P577
2005-08-11T00:00:00Z