Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor
about
Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorA single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Evolutionary history and functional characterization of the amphibian xenosensor CAR.Activation of xenobiotic receptors: driving into the nucleus.Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducersTranscription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicityCAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptorDifferential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineMulti-species analyses of direct activators of the constitutive androstane receptor.Small-molecule modulators of the constitutive androstane receptor.Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.Small-molecule modulators of PXR and CAR.Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoformsThe orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Compartment-specific gene regulation of the CAR inducer efavirenz in vivo.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectivePharmacogenetics of the constitutive androstane receptor.Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.Naturally occurring C-terminal splice variants of nuclear receptors.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analoguesHuman glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology.Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy.Orphan nuclear receptors as targets for drug development.Xenobiotic receptor humanized mice and their utility.Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Nuclear receptors and nonalcoholic fatty liver disease.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.Constitutive androstane receptor regulates the intestinal mucosal response to injury.A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor-Targeted Drug-Processing Genes in the Liver.Allosteric pathways in nuclear receptors - Potential targets for drug design.
P2860
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P2860
Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Alternative splicing affects t ...... nstitutive androstane receptor
@ast
Alternative splicing affects t ...... nstitutive androstane receptor
@en
Alternative splicing affects t ...... nstitutive androstane receptor
@nl
type
label
Alternative splicing affects t ...... nstitutive androstane receptor
@ast
Alternative splicing affects t ...... nstitutive androstane receptor
@en
Alternative splicing affects t ...... nstitutive androstane receptor
@nl
prefLabel
Alternative splicing affects t ...... nstitutive androstane receptor
@ast
Alternative splicing affects t ...... nstitutive androstane receptor
@en
Alternative splicing affects t ...... nstitutive androstane receptor
@nl
P2093
P2860
P356
P1433
P1476
Alternative splicing affects t ...... nstitutive androstane receptor
@en
P2093
Katja A Arnold
Michel Eichelbaum
Oliver Burk
P2860
P2888
P356
10.1186/1478-1336-2-1
P577
2004-03-25T00:00:00Z
P5875
P6179
1039488148