The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.
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Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes.Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assemblyThe MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationIdentification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene.Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice.Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner.Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency.The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cellsTyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivoImmune escape of γ-herpesviruses from adaptive immunityEpstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation.Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytesMurine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cellsIdentification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation.Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cellsSystematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells.Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade.Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latencyIdentification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication.Murine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP-1.Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses.Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo.Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2.CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic.Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells.Gamma-herpesvirus colonization of the spleen requires lytic replication in B cells.
P2860
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P2860
The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@ast
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@en
type
label
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@ast
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@en
prefLabel
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@ast
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@en
P2093
P2860
P1433
P1476
The murine gammaherpesvirus 68 ...... rom latently infected B cells.
@en
P2093
Jeremy H Herskowitz
Meagan A Jacoby
Samuel H Speck
P2860
P304
P356
10.1128/JVI.79.4.2261-2273.2005
P577
2005-02-01T00:00:00Z