Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency.
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Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationIdentification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene.Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters.Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivoThe murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.Characterization of a novel wood mouse virus related to murid herpesvirus 4.Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68.Identification of proteins associated with murine gammaherpesvirus 68 virions.Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation.Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome.Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes.Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistenceGammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivoA conserved RNA polymerase III promoter required for gammaherpesvirus TMER transcription and microRNA processing.Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5.Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.Expression in a recombinant murid herpesvirus 4 reveals the in vivo transforming potential of the K1 open reading frame of Kaposi's sarcoma-associated herpesvirusGamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner.The m4 gene of murine gammaherpesvirus modulates productive and latent infection in vivo.NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection.Granzymes and caspase 3 play important roles in control of gammaherpesvirus latencyAlpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency.Role for MyD88 signaling in murine gammaherpesvirus 68 latency.Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo.
P2860
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P2860
Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency.
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2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Characterization of a spontane ...... etic requirements for latency.
@ast
Characterization of a spontane ...... etic requirements for latency.
@en
Characterization of a spontane ...... etic requirements for latency.
@nl
type
label
Characterization of a spontane ...... etic requirements for latency.
@ast
Characterization of a spontane ...... etic requirements for latency.
@en
Characterization of a spontane ...... etic requirements for latency.
@nl
prefLabel
Characterization of a spontane ...... etic requirements for latency.
@ast
Characterization of a spontane ...... etic requirements for latency.
@en
Characterization of a spontane ...... etic requirements for latency.
@nl
P2860
P1433
P1476
Characterization of a spontane ...... etic requirements for latency.
@en
P2093
Eric T Clambey
Samuel H Speck
P2860
P304
P356
10.1128/JVI.76.13.6532-6544.2002
P407
P577
2002-07-01T00:00:00Z