Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation.
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Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral ImmunityRole of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes.Identification of candidate gammaherpesvirus 68 genes required for virus replication by signature-tagged transposon mutagenesis.Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assemblyThe MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationIdentification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene.A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirusInduction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency.Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivoThe murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells.Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.Characterization of a novel wood mouse virus related to murid herpesvirus 4.Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis.Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cellsTyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivoA gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality.Gamma interferon blocks gammaherpesvirus reactivation from latency.A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge.Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency.Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation.No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection.Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome.Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytesChemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural hostMurine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cellsSelective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes.Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infectionEstablishment of murine gammaherpesvirus latency in B cells is not a stochastic event.Functions and mechanisms of action of the adenovirus E3 proteins.Type I Interferons Direct Gammaherpesvirus Host ColonizationViruses with deletions in antiapoptotic genes as potential oncolytic agents.Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cellsGamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cellsSystematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.
P2860
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P2860
Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation.
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2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@ast
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@en
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@nl
type
label
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@ast
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@en
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@nl
prefLabel
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@ast
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@en
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@nl
P2860
P1433
P1476
Disruption of the M2 gene of m ...... intraperitoneal, inoculation.
@en
P2093
Meagan A Jacoby
Samuel H Speck
P2860
P304
P356
10.1128/JVI.76.4.1578-1587.2002
P407
P577
2002-02-01T00:00:00Z