TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. - Wikidata - awgldk - TriplyDB

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

http://www.wikidata.org/entity/Q37148469

about

Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.The role of TDP1 and APTX in mitochondrial DNA repair.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.Pre-steady state kinetics of DNA binding and abasic site hydrolysis by tyrosyl-DNA phosphodiesterase 1.A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Starting over: Primpol reprimes after chain termination.HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin.Role of Protein Linked DNA Breaks in Cancer.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution.Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

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TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

http://www.wikidata.org/entity/Q37148469

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 June 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

@en

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

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type

label

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

@en

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

@nl

prefLabel

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

@en

TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

@nl

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Nucleic Acids Research

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TDP1 repairs nuclear and mitoc ...... antiviral nucleoside analogs.

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Alena Naumova

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Junko Murai

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Shar-yin N Huang

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Thomas S Dexheimer

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William H Gmeiner

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P2860

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy

Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

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7793-7803

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scholarly article

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10.1093/NAR/GKT483

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16

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41

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Ilaria Dalla Rosa

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2013-06-17T00:00:00Z

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239734472

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23775789

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mitochondrial DNA

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3763526

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