Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia
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Role of microglia in central nervous system infectionsA small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activityWill multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitroDeterminants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domainsIn vivo monocyte tropism of pathogenic feline immunodeficiency virusesAnalysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization.Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementiaSecreted respiratory syncytial virus G glycoprotein induces interleukin-5 (IL-5), IL-13, and eosinophilia by an IL-4-independent mechanism.Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolatesMononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementiaMacrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity.Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion.A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages.A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia.Chemokine CXCL8 promotes HIV-1 replication in human monocyte-derived macrophages and primary microglia via nuclear factor-κB pathway.The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression.Human retinal microglia express candidate receptors for HIV-1 infection.Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages.HIV-infected microglia mediate cathepsin B-induced neurotoxicity.CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection.Rabbit Models for Studying Human Infectious Diseases.Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS.The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitorsA single amino acid change and truncated TM are sufficient for simian immunodeficiency virus to enter cells using CCR5 in a CD4-independent pathway.Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype.Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and Spread.Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates.Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion.Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope.Expanded tropism of primary human immunodeficiency virus type 1 R5 strains to CD4(+) T-cell lines determined by the capacity to exploit low concentrations of CCR5.Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia.Antiviral properties of two trimeric recombinant gp41 proteins.CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis.
P2860
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P2860
Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@ast
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@en
type
label
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@ast
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@en
prefLabel
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@ast
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@en
P2093
P2860
P1433
P1476
Role of the beta-chemokine rec ...... ion of monocytes and microglia
@en
P2093
A Ghorpade
C R Mackay
H E Gendelman
Y Persidsky
P2860
P304
P577
1998-04-01T00:00:00Z