CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
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Theiler's virus infection: a model for multiple sclerosisHuman HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic DemyelinationMultiple Sclerosis and T Lymphocytes: An Entangled StoryDifferential influence of interleukin-12 in the pathogenesis of autoimmune and virus-induced central nervous system demyelination.Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelinationNeuroimmune interactions in a model of multiple sclerosis.A critical role for virus-specific CD8(+) CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice.Novel roles of the picornaviral 3D polymerase in viral pathogenesis.Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis.Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence.Absence of perforin expression confers axonal protection despite demyelination.Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.Virus-induced demyelination in nude mice is mediated by gamma delta T cells.Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosisOral administration of live virus protects susceptible mice from developing Theiler's virus-induced demyelinating disease.Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reactionEpitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosisT cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitisCD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.Anticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice.Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease.IFNγ influences type I interferon response and susceptibility to Theiler's virus-induced demyelinating diseaseInflammation on the mind: visualizing immunity in the central nervous system.Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models.Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.Human class I major histocompatibility complex alleles determine central nervous system injury versus repair.CD8(+) T cells in multiple sclerosis.Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosisCellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cordRoles of regulatory T cells and IL-10 in virus-induced demyelination.Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infectionFollowing Acute Encephalitis, Semliki Forest Virus is Undetectable in the Brain by Infectivity Assays but Functional Virus RNA Capable of Generating Infectious Virus Persists for Life.
P2860
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P2860
CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
@ast
CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
@en
type
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CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
@ast
CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
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prefLabel
CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
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CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
@en
P2093
P2860
P1433
P1476
CD4(+) and CD8(+) T cells make ...... al model of multiple sclerosis
@en
P2093
P2860
P304
P577
1998-09-01T00:00:00Z