Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
about
Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode DependentBim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.The use of structural biology in Janus kinase targeted drug discovery.Selective JAK inhibitors.Inhibitor-based affinity probes for the investigation of JAK signaling pathways.Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.Ligand-based and e-pharmacophore modeling, 3D-QSAR and hierarchical virtual screening to identify dual inhibitors of spleen tyrosine kinase (Syk) and janus kinase 3 (JAK3).Pharmacophore and docking-based virtual screening approach for the design of new dual inhibitors of Janus kinase 1 and Janus kinase 2.
P2860
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P2860
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@ast
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@en
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@nl
type
label
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@ast
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@en
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@nl
prefLabel
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@ast
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@en
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@nl
P2093
P50
P1476
Discovery and SAR of potent, o ...... a new class of JAK2 inhibitors
@en
P2093
Christoph Gaul
Clive McCarthy
Flavio Ossola
Francesca Blasco
Giorgio Ottaviani
Gisele A Tavares
Janitha Reetz
Julien Scesa
Marc Gerspacher
Pascal Furet
P304
P356
10.1016/J.BMCL.2010.02.056
P407
P577
2010-04-15T00:00:00Z