The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
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Nucleophosmin: from structure and function to disease developmentAcute Myeloid Leukemia: A Concise ReviewNovel Prognostic and Therapeutic Mutations in Acute Myeloid LeukemiaZebrafish as a model for leukemia and other hematopoietic disordersMutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms.Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironmentLeukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant TransportPreclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaMutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia.Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia.Is acute myeloid leukemia a liquid tumor?NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Genomics of acute myeloid leukemia: the next generation.Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia.Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development.How does the NPM1 mutant induce leukemia?Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.Biological and clinical consequences of NPM1 mutations in AML.Nucleophosmin delocalization in thyroid tumour cells.NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells.Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemiaMutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in miceAn intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus.Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia.
P2860
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P2860
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@ast
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@en
type
label
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@ast
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@en
prefLabel
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@ast
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@en
P2093
P2860
P1433
P1476
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
@en
P2093
Jeffery L Kutok
John G Clohessy
Keisuke Ito
Paolo Sportoletti
P2860
P304
P356
10.1182/BLOOD-2009-03-208587
P407
P577
2009-08-07T00:00:00Z