Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.
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NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin RemodelingDistinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosminMolecules that target nucleophosmin for cancer treatment: an updateAcute Myeloid Leukemia: A Concise ReviewStructural Basis of Targeting the Exportin CRM1 in CancerNuclear export of proteins and drug resistance in cancerStructural Consequences of Nucleophosmin Mutations in Acute Myeloid LeukemiaAntileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsBET inhibitors in the treatment of hematologic malignancies: current insights and future prospectsNovel Prognostic and Therapeutic Mutations in Acute Myeloid LeukemiaClinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise reviewHistone chaperones link histone nuclear import and chromatin assemblyCan cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Nucleophosmin and nucleolin regulate K-Ras signaling.Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNARecognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation.Performance and clinical evaluation of a sensitive multiplex assay for the rapid detection of common NPM1 mutationsThe NPM1 mutation type has no impact on survival in cytogenetically normal AML.Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemiaCytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc)Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsA knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironmentElucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosminNucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.Quantitative detection of circulating nucleophosmin mutations DNA in the plasma of patients with acute myeloid leukemia.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinicMonoclonal antibodies against nucleophosmin mutants: potentials for the detection of acute myeloid leukemia.Identification of inhibitors of biological interactions involving intrinsically disordered proteins.Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?Altered HLA Class I Profile Associated with Type A/D Nucleophosmin Mutation Points to Possible Anti-Nucleophosmin Immune Response in Acute Myeloid LeukemiaLeukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant TransportCytoplasmic nucleophosmin has elevated T199 phosphorylation upon which G2/M phase progression is dependent.Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaSequence and structural analyses of nuclear export signals in the NESdb databaseInteractions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants.Identification of two novel NPM1 mutations in patients with acute myeloid leukemiaNucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
P2860
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P2860
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Both carboxy-terminus NES moti ...... leukemic mutants in NPMc+ AML.
@en
type
label
Both carboxy-terminus NES moti ...... leukemic mutants in NPMc+ AML.
@en
prefLabel
Both carboxy-terminus NES moti ...... leukemic mutants in NPMc+ AML.
@en
P2093
P1433
P1476
Both carboxy-terminus NES moti ...... leukemic mutants in NPMc+ AML.
@en
P2093
Alessandra Pucciarini
Andrea Biondi
Arcangelo Liso
Barbara Bigerna
Brunangelo Falini
Cristina Mecucci
Daniela Diverio
Enrico Tiacci
Giovanni Cazzaniga
Giovanni Roti
P304
P356
10.1182/BLOOD-2005-11-4745
P407
P577
2006-02-02T00:00:00Z