mdm2: a bridge over the two tumour suppressors, p53 and Rb.
about
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulatorp38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisHighlight: BRCA1 and BRCA2 proteins in breast cancerLoss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells.Simian virus 40 large T antigen and two independent T-antigen segments sensitize cells to apoptosis following genotoxic damageProtein kinase CK2 in health and disease: CK2: a key player in cancer biologyModelling the onset of senescence at the G1/S cell cycle checkpoint.A Model for p38MAPK-Induced Astrocyte SenescenceMolecular approaches to sarcoma therapy.Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.Cellular Senescence - its role in cancer and the response to ionizing radiation.MDM2's social network.p53-independent effects of Mdm2.Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function.EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein.Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage.p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells.Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes.Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.Effect of etoposide-induced alteration of the Mdm2-Rb signaling pathway on cellular senescence in A549 lung adenocarcinoma cells.Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors.p53: only ARF the story.Adenovirus-mediated p16INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner.E3 ubiquitin ligases in cancer and implications for therapies.Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study.Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5
P2860
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P2860
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@ast
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@en
type
label
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@ast
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@en
prefLabel
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@ast
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@en
P2093
P2860
P356
P1433
P1476
mdm2: a bridge over the two tumour suppressors, p53 and Rb.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1202954
P407
P577
1999-12-01T00:00:00Z
P5875
P6179
1045257156