Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
about
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformationSelective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epitheliumCombined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor developmentCyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulationCell cycle proteins as promising targets in cancer therapyc-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.A CDK2 activity signature predicts outcome in CDK2-low cancers.Cdk2 suppresses cellular senescence induced by the c-myc oncogene.Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation.Characterization of hair-follicle side population cells in mouse epidermis and skin tumors.Identification of cell cycle-targeting microRNAs through genome-wide screens.
P2860
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P2860
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@ast
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@en
type
label
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@ast
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@en
prefLabel
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@ast
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@en
P2093
P2860
P1433
P1476
Cdk2 deficiency decreases ras/ ...... not myc-induced tumorigenesis
@en
P2093
Andres Klein-Szanto
Everardo Macias
Marcelo L Rodriguez-Puebla
Paula L Miliani de Marval
Yongbaek Kim
P2860
P304
P356
10.1158/0008-5472.CAN-07-2119
P407
P577
2007-10-01T00:00:00Z