Cdk2 suppresses cellular senescence induced by the c-myc oncogene. - Wikidata - awgldk - TriplyDB

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

http://www.wikidata.org/entity/Q39763259

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Synthetic lethal screens as a means to understand and treat MYC-driven cancers Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation Disruption of clathrin-mediated trafficking causes centrosome overduplication and senescence.Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control Deciphering c-MYC-regulated genes in two distinct tissues.Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.MYC and the control of DNA replication.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway.Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.MYC cofactors: molecular switches controlling diverse biological outcomes.Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.The essence of senescence.The retrograde response: a conserved compensatory reaction to damage from within and from without.Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.Astrocyte elevated gene-1 and c-Myc cooperate to promote hepatocarcinogenesis in mice.SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.Human neonatal cardiovascular progenitors: unlocking the secret to regenerative ability.Gerosuppressant metformin: less is more SUMOylation of Myc-family proteins R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis.The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.Novel ARF/p53-independent senescence pathways in cancer repression.Myc proteins in brain tumor development and maintenance.The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction.Functional genomics identifies therapeutic targets for MYC-driven cancer.Decreased skp2 expression is necessary but not sufficient for therapy-induced senescence in prostate cancer Strategies to Inhibit Myc and Their Clinical Applicability The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype.Targeting MYC in cancer therapy: RNA processing offers new opportunities.Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

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P2860

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

http://www.wikidata.org/entity/Q39763259

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@en

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@nl

type

label

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@en

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@nl

prefLabel

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@en

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

@nl

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Nature Cell Biology

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Cdk2 suppresses cellular senescence induced by the c-myc oncogene

@en

P2093

Alessandro Verrecchia

http://www.w3.org/2001/XMLSchema#string

Daniele Perna

http://www.w3.org/2001/XMLSchema#string

Domenico Sardella

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Lars-Gunnar Larsson

http://www.w3.org/2001/XMLSchema#string

Lucia Bianchi

http://www.w3.org/2001/XMLSchema#string

Mariano Barbacid

http://www.w3.org/2001/XMLSchema#string

Matilde Murga

http://www.w3.org/2001/XMLSchema#string

Per Hydbring

http://www.w3.org/2001/XMLSchema#string

Susanna Tronnersjö

http://www.w3.org/2001/XMLSchema#string

Thomas Schleker

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P2860

Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

c-Myc accelerates S-phase and requires WRN to avoid replication stress

Cdk2 knockout mice are viable

Non-transcriptional control of DNA replication by c-Myc

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Cellular senescence: when bad things happen to good cells

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

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P304

54-9; sup pp 1-14

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scholarly article

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10.1038/NCB2004

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1

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12

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Oscar Fernandez-Capetillo

Stefano Campaner

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2009-12-13T00:00:00Z

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40688310

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20010815

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