Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction
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Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligandsComplementary and Alternative Therapies in Amyotrophic Lateral SclerosisComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Pharmacological characterization of GPR55, a putative cannabinoid receptorNovel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells.Cannabinoid receptors: nomenclature and pharmacological principlesNovel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorMass spectrometry-based GPCR proteomics: comprehensive characterization of the human cannabinoid 1 receptor.Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranesTransmembrane helical domain of the cannabinoid CB1 receptor.Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi.Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment.ALSUntangled No. 16: cannabis.Distinct second extracellular loop structures of the brain cannabinoid CB(1) receptor: implication in ligand binding and receptor functionCannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.CB1 and CB2 Receptor Pharmacology.
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P2860
Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mapping the structural require ...... lix II for signal transduction
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Mapping the structural require ...... ix II for signal transduction.
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type
label
Mapping the structural require ...... lix II for signal transduction
@en
Mapping the structural require ...... ix II for signal transduction.
@nl
prefLabel
Mapping the structural require ...... lix II for signal transduction
@en
Mapping the structural require ...... ix II for signal transduction.
@nl
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P1476
Mapping the structural require ...... lix II for signal transduction
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Ankur Kapur
Ganesh A Thakur
Mary E Abood
Patrick Samaniego
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10.1124/JPET.107.133256
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P577
2008-01-03T00:00:00Z