CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development - Wikidata - awgldk - TriplyDB

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

http://www.wikidata.org/entity/Q33832059

about

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45 T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters CD28 sensitizes TCR Ca²⁺ signaling during Ag-independent polarization of plasma membrane rafts.Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.Small molecule inhibition of Csk alters affinity recognition by T cells.High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.Endogenous antigen tunes the responsiveness of naive B cells but not T cells LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.An extracatalytic function of CD45 in B cells is mediated by CD22.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.Functional development of the T cell receptor for antigen Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.Insights into the initiation of TCR signaling.Molecular and genetic parameters defining T-cell clonal selection.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.Signaling in lymphocyte activation.Receptor signaling in immune cell development and function.Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data.Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells.How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

P2860

Q24297041-6B0056D2-D22C-4193-A4E8-FBCB1EF915BB Q26781282-C6CB4E4A-95A0-473E-A087-7C58F9470938 Q28510998-A02EB13D-932A-4268-838E-F3F51A8CFFBA Q30539168-A81445A5-B238-4B29-8DA2-41D830068A9D Q33690511-B7A957DB-4BFC-4FFF-877B-3363D128C605 Q33770073-81E63A81-C371-4438-961A-BF3F9E0FB581 Q34317431-AC74798A-60B4-428D-9C6F-673AE02986D4 Q34460867-9AECBFCE-D64D-468F-8746-ABC5C28CDF0A Q34998251-7C940A28-15B9-4707-921A-87B16229E596 Q35063027-D2554AC4-5080-481E-AEA1-AB756D677914 Q35232854-06B47338-B205-4453-A68B-ECD5769891B7 Q35651974-87531702-608B-47EB-B91E-86ED9FA7DA0E Q35657860-3BD09D4A-3E74-457F-BC4A-596F01FF59F2 Q36037522-FA1FE083-BC74-407F-BE7E-FEEBA362AF17 Q36056553-94B12F98-7AEB-44D0-94E4-08105241262C Q36212888-E569DC04-5729-49A3-A0DF-FD782BFBF86F Q36223587-DBA802CD-C532-4917-BF7E-5713E9F55232 Q36227411-0B20BCB5-BAFE-48C4-86C8-418C9A1264CD Q36332105-81F74789-C9EA-43C5-9945-9966AABCE852 Q36487572-8A76DC11-250B-4E38-BBCE-8A23B2AC90EA Q36672815-3732F0D6-0C16-42F9-BAEC-927572EE251B Q36780944-21DF2F9C-430D-4C2D-A76C-8E6136BEAB74 Q36802757-45ED4038-1353-44C9-89EE-FD119476C479 Q36873274-E632B9EC-2701-4EB0-8EF8-7DB9F61A2FF7 Q36951583-063C47DF-E20E-4218-8DD3-B0C738F43D5E Q37066101-59FF0C92-5798-480C-AF1D-C4127A437F9E Q37162653-5C8DA373-E84C-4DEF-97D8-98F911160516 Q37548431-F2DB0DB9-D7E7-43B9-92D3-1ABBFC690206 Q37580455-C246B092-7F25-4A22-976B-82CE6A7CEC1C Q37801270-7BA77B65-A692-4477-B579-2097F3ABC738 Q38031978-C6A80F75-8010-48FB-8DF0-4984026680C4 Q38263872-01423985-9091-4A37-9667-167E06732B4D Q38511575-1556EE1C-3429-45E7-8280-9ABB14B54F55 Q38711461-7B28E357-5712-45D3-A2C0-1C2C3DCB67D3 Q41349893-4AE7730F-9A2F-4583-BD97-A39493CAB1B6 Q41580820-BF9E2D7A-D1B0-41A9-BB93-766D0FF8DC63 Q41880484-1191AB41-C837-47E5-94CE-27340FA97E9B Q42205932-FC0D02B0-50B5-49AF-AE2B-3C54F5A49A49 Q43086838-98BCF428-669E-48CD-8BED-7994C24EE2D6 Q44384732-3D83A3ED-8708-425A-B765-3B259A082EA7

P2860

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

http://www.wikidata.org/entity/Q33832059

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@ast

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@en

type

label

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@ast

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@en

prefLabel

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@ast

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@en

P1433

Q33832059-31E47903-CD3C-4C3C-89DB-D29CA8946379

P1476

Q33832059-55D0384B-5FE3-48F6-B51E-843AC5B37FDC

P2093

Q33832059-0A8BF695-1A41-43AE-B2CC-CAE625770901

Q33832059-1AD71087-817F-41F1-B3F1-5F31D707994A

Q33832059-3ABB99D1-832D-4FD0-AA6B-1E14ED5040D2

Q33832059-6DFDA420-466C-4954-8ACB-798C16E77A38

Q33832059-71ACC12E-9E1D-424F-A586-5AAD94AB90B9

Q33832059-BB31DE93-1771-4F9F-9287-DE1A9123C40D

P2860

Q33832059-0A9B5CDF-78B2-404D-A67A-AE238748DE38

Q33832059-14990D89-8411-4272-8C9D-D626CC9C194E

Q33832059-15063F24-0A15-4EB7-BEAC-D01E83E4911D

Q33832059-1C7F210D-BAE6-43AB-A694-1BD6B382A1BB

Q33832059-1CA697C4-4829-4A86-B87E-93D6C4A1F8BD

Q33832059-25D350BC-86CF-430A-9512-562849675057

Q33832059-262A2995-706C-4904-AAEF-A79635AE663B

Q33832059-2904BF82-08CA-495C-8EB5-D0715DA8FC8F

Q33832059-317F0290-72FD-413D-B0B7-DC9009A8363E

Q33832059-32E7700F-8DD5-47FA-8045-E33E1D3FFB5E

P304

Q33832059-D37427E8-09B8-4EEC-A5B5-A1AF9589178B

P31

Q33832059-F81052B2-4FE5-481E-940C-24F70FD537FE

P356

Q33832059-8609A572-29D4-4C56-BA1D-A2B5947376E7

P407

Q33832059-1FCB25F8-06EB-4C61-8F54-1957F2A14FF9

P433

Q33832059-4E6555EC-3AF8-41E2-8972-2208FEDF0DE3

P478

Q33832059-9E0961CF-835C-48A2-9AE1-F113B68F9A87

P50

Q33832059-1947E081-F247-4869-8459-6C183AA22DD3

P577

Q33832059-3CE45605-251A-4BBA-9E23-983E1FE15C3A

P5875

Q33832059-8C1C74DA-41FF-482B-A415-9E80D888CB49

P698

Q33832059-31CD1F6E-87B7-41E5-9617-C1934359B091

P932

Q33832059-B3277A39-1D1B-4D41-849B-9B0E9BD7890B

P356

J.IMMUNI.2010.03.006

P1433

P1476

CD45-Csk phosphatase-kinase ti ...... ling during thymic development

@en

P2093

Christopher C Goodnow

http://www.w3.org/2001/XMLSchema#string

Craig Jenne

http://www.w3.org/2001/XMLSchema#string

Julie Zikherman

http://www.w3.org/2001/XMLSchema#string

Kristin Doan

http://www.w3.org/2001/XMLSchema#string

Susan Watson

http://www.w3.org/2001/XMLSchema#string

William Raschke

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

P304

342-354

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.IMMUNI.2010.03.006

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

32

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

42609501

http://www.w3.org/2001/XMLSchema#string

P698

20346773

http://www.w3.org/2001/XMLSchema#string

P932

2865198

http://www.w3.org/2001/XMLSchema#string