Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. - Wikidata - awgldk - TriplyDB

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.

http://www.wikidata.org/entity/Q33832866

about

Development of autophagy inducers in clinical medicine The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy Mechanisms of RNA-induced toxicity in CAG repeat disorders Autophagy and neurodegeneration Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Intrabodies as neuroprotective therapeutics Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Autophagy modulation as a potential therapeutic target for diverse diseases Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons Therapeutic Targeting of Autophagy Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases Impaired clearance of apoptotic cells in chronic inflammatory diseases: therapeutic implications Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency Signals from the lysosome: a control centre for cellular clearance and energy metabolism.Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.Hot topics in aging research: protein translation and TOR signaling, 2010 Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration Autophagy failure in Alzheimer's disease--locating the primary defect.Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Gene therapy in mouse models of huntington disease.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.α-Synuclein levels modulate Huntington's disease in mice.Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins.Computational model for autophagic vesicle dynamics in single cells.The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells.Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging.A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.Protein misfolding disorders and macroautophagy.Autophagy and misfolded proteins in neurodegeneration.Role of autophagy in cancer prevention.Autophagy and polyglutamine diseases.Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins Control of autophagy as a therapy for neurodegenerative disease.

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P2860

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.

http://www.wikidata.org/entity/Q33832866

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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type

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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P1433

Human Molecular Genetics

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Rilmenidine attenuates toxicit ...... model of Huntington's disease.

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P2093

Claudia Rose

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David C Rubinsztein

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Fiona M Menzies

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Maurizio Renna

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Oana Sadiq

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Steve D Brown

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P2860

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

Growing roles for the mTOR pathway

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

Potential therapeutic applications of autophagy

Drugs acting on imidazoline receptors: a review of their pharmacology, their use in blood pressure control and their potential interest in cardioprotection.

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10.1093/HMG/DDQ093

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11

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19

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Silvia Corrochano

Abraham Acevedo-Arozena

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2010-02-27T00:00:00Z

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41622854

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20190273

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P921

Huntington disease

P932

2865373

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