Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
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The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replicationRSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesisTransforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor proteinDeregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerMislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapyA novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cellsSomatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitorRPLP1, a crucial ribosomal protein for embryonic development of the nervous systemThe human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling.PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.CARP is a potential tumor suppressor in gastric carcinoma and a single-nucleotide polymorphism in CARP gene might increase the risk of gastric carcinoma.Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionPregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cellsp27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.Increased cytoplasmic localization of p27(kip1) and its modulation of RhoA activity during progression of chronic myeloid leukemia.Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancerSiah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zoneP27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori.A novel function for Cyclin A2: control of cell invasion via RhoA signaling.Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsDiscovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotypeMENX and MEN4Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitorsGenetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.p27(KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouse.Mutant AKT1-E17K is oncogenic in lung epithelial cellsGenetic screening reveals an essential role of p27kip1 in restriction of breast cancer progressionPI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.TRIP6 regulates p27 KIP1 to promote tumorigenesis.Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.
P2860
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P2860
Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@ast
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@en
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@nl
type
label
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@ast
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@en
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@nl
prefLabel
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@ast
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@en
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@nl
P2093
P2860
P1476
Novel p27(kip1) C-terminal sca ...... of cell cycle arrest functions
@en
P2093
Giuseppe Pintucci
Michele Pagano
Michelle Becker-Hapak
Sandra S McAllister
Steven F Dowdy
P2860
P304
P356
10.1128/MCB.23.1.216-228.2003
P407
P577
2003-01-01T00:00:00Z