Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.
about
4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation Product4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cellsPhenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome.Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenalIdentification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal4-HNE increases intracellular ADMA levels in cultured HUVECs: evidence for miR-21-dependent mechanismsExploring the biology of lipid peroxidation-derived protein carbonylation.Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosisProtein carbonylation, mitochondrial dysfunction, and insulin resistance.Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosisA chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles.Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease.Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies.Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity.Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation.4-hydroxynonenal-mediated signaling and aging.Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells.Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.Steatosis-induced proteins adducts with lipid peroxidation products and nuclear electrophilic stress in hepatocytes.In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition.Hyperlipidemia-induced hepatic and small intestine ER stress and decreased paraoxonase 1 expression and activity is associated with HDL dysfunction in Syrian hamsters.Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.
P2860
Q26782039-54267B8A-0C60-4DC8-95AB-C8423A8D12DFQ28389200-2F3A4AE0-811A-4B3B-8DC0-C188B8EE6BCBQ33636467-451FD469-4C13-4BD8-AC62-AC231810967BQ33685055-543EC20C-395F-4F0E-A43F-08681A69EF3BQ33790988-6063F191-C377-4D05-999A-29D1D111FDFAQ34075939-69C1CF03-1271-44B3-8C86-2B74F15E447AQ34248839-69BFEFD8-0854-4A50-AB6B-268AF78093FFQ34745328-AD0E4E6F-BD6F-4B88-9565-C4A0667D139FQ35226317-83E6A6C8-47AF-4B10-82A7-6C2347B0E78CQ36602713-DFA71E47-41F2-4774-9963-539BB0579B53Q36829659-FED03395-AEB5-4931-90BB-3A7169AC309AQ37384680-236C76D8-FC59-4A27-8FC3-FDDF1099E602Q37513287-D153F1FB-E6F6-41E8-B7C8-DCA32C33AA4EQ37594392-E5ADC4DC-6F38-4C99-A422-AF919BC112A3Q37621344-6678FE69-16DF-46AE-8E9D-9D53B4E8C7D5Q38119881-6397A99A-7099-44AE-9BE3-A0EBCB843ED7Q38994289-AA527F22-A1BE-4FDA-BF34-AD957F67C90EQ39007088-578EDFCB-DAD8-47B1-BCF2-B701D57237BDQ39017103-74BF61BC-9067-4A9F-8CFC-80896AC88860Q39349474-FC8B2C3B-BD36-4D1E-9380-14B86597F13CQ42009639-EC208ECA-45F6-4103-96B7-8C111D24ABB1Q42131040-AC61D273-F3A0-4654-A7CE-E1EAB5030364Q46762183-F5981358-AB60-45EB-9527-EEFB83CC8E9AQ47359239-D953C6BF-5FFC-48C0-BE46-4A29DA17F956Q47680877-DF8577E8-916C-445C-8E71-AD983E0A6C0AQ48585200-035F0759-AD81-4EBD-971C-8C63CC9A8011Q51741393-2FAAC13D-8214-4859-BC4E-FBA7BEABC565Q54535150-1524E213-69EB-4430-BA2D-E24BED1D9B04Q55385168-1E277D70-08F4-4FB3-8A74-AB17B108E771
P2860
Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@ast
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@en
type
label
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@ast
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@en
prefLabel
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@ast
Modification of Akt2 by 4-hydr ...... Akt signaling in HepG2 cells.
@en
P2093
P356
P1433
P1476
Modification of Akt2 by 4-hydr ...... t Akt signaling in HepG2 cells
@en
P2093
C T Shearn
Dennis R Petersen
P304
P356
10.1021/BI200029W
P407
P577
2011-04-20T00:00:00Z