Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.
about
Siderophore-based iron acquisition and pathogen controlBiochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domainMechanistic analysis of Mycobacterium tuberculosis Rv1347c, a lysine Nepsilon-acyltransferase involved in mycobactin biosynthesisA mechanism-based aryl carrier protein/thiolation domain affinity probe.Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategySynthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosisStructural Biology of Nonribosomal Peptide Synthetases5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.Iron trafficking as an antimicrobial targetAryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis.Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosisMultisubstrate adduct inhibitors: drug design and biological tools.Update on carbohydrate-containing antibacterial agents.Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestisQuantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.Models for antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines.Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.
P2860
Q24681774-67AF461C-3929-4810-B0F9-7935E24384FFQ27664601-306388C0-1453-46B8-96EF-5A30DFD4180AQ28487064-A021A2CF-853B-4A79-9822-F4EAC6452464Q28487185-A9281A6F-A4EC-490C-8F55-3B94CBF447CAQ33283240-E3957135-94F3-4053-9FB8-F02323D18E5AQ33565674-6067CC54-234A-4D06-98DF-61381F05F44CQ33746313-618165A4-AFE4-4C8C-8446-346421C18F9FQ34622456-855AE3BF-4FA3-4B35-90BD-49487BB7B87AQ35688927-A1E07FE2-06A4-4962-B504-AF6C03AD256BQ36341699-F3A9FEC6-84DB-4BF5-9742-7E3DB021A078Q36597567-202A3313-7F99-41FD-AA8E-95B02CCDF856Q36883611-58790248-D2D3-4B19-AC0B-FEA1FEF8823EQ37092084-1EEA421D-E462-48D7-9E3E-F7BB29685CF1Q37125144-411BAA56-D182-4EDF-9C58-17207624C367Q37137597-DC81D6E6-E882-4959-AFFF-B4E71EBB4973Q37196170-92417DE4-2035-4D00-BA8D-6B80E99105BEQ37257062-1E883EC7-8E87-4241-A0CA-C69EEC9505C1Q37292453-745D7206-3B12-4E35-9A92-ED4A823D44AAQ37361251-E0BF12A0-575B-4723-8302-72268371E149Q37632419-FBEBE5F1-7988-4B8F-8217-AD2DFC66FA01Q38089193-521BC119-0CB7-4589-B21F-9437609BF945Q39255222-996EB43A-48B2-4998-B38C-D3DE031EBFF1Q40523880-9064B5CF-0489-46DF-9BAA-4EB6F45F4DEAQ41376285-DAFC5436-952A-4BC3-A425-D6C5653FA257Q42793538-7715C646-600B-4BBA-BDB2-01282410B308Q53072956-E55F9221-B34B-4964-B74F-EF8503AE7A3D
P2860
Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2006
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Design, synthesis, and biologi ...... tential antitubercular agents.
@en
Design, synthesis, and biologi ...... tential antitubercular agents.
@nl
type
label
Design, synthesis, and biologi ...... tential antitubercular agents.
@en
Design, synthesis, and biologi ...... tential antitubercular agents.
@nl
prefLabel
Design, synthesis, and biologi ...... tential antitubercular agents.
@en
Design, synthesis, and biologi ...... tential antitubercular agents.
@nl
P2093
P2860
P356
P1433
P1476
Design, synthesis, and biologi ...... tential antitubercular agents.
@en
P2093
Courtney C Aldrich
Daniel J Wilson
Eric M Bennett
Helena I Boshoff
Jagadeshwar Vannada
P2860
P304
P356
10.1021/OL0617289
P407
P577
2006-10-01T00:00:00Z