Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. - Wikidata - awgldk - TriplyDB

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

http://www.wikidata.org/entity/Q33874580

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The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction The Philadelphia chromosome in leukemogenesis MicroRNAs in B cell development and malignancy Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells BCR-ABL affects STAT5A and STAT5B differentially Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.Future alternative therapies for β-thalassemia.STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1.Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B.The different functions of Stat5 and chromatin alteration through Stat5 proteins Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung Akt is required for Stat5 activation and mammary differentiation.Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.Nonredundant roles for Stat5a/b in directly regulating Foxp3 Abnormal hematopoiesis in Gab2 mutant mice Critical requirement for Stat5 in a mouse model of polycythemia vera.Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.Diverging fates of cells of origin in acute and chronic leukaemia.Fell Pony syndrome: characterization of developmental hematopoiesis failure and associated gene expression profiles.Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.IL-2 regulates expression of C-MAF in human CD4 T cells STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

http://www.wikidata.org/entity/Q33874580

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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type

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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BLOOD-2005-09-3596

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Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

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Andrea Hoelbl

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Hartmut Beug

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Marc A Kerenyi

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Olivia Simma

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Veronika Sexl

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Wolfgang Warsch

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Yongzhi Cui

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P2860

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

TYK2 is a key regulator of the surveillance of B lymphoid tumors

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

STAT5 is required for thymopoiesis in a development stage-specific manner

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Stats: transcriptional control and biological impact

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4898-4906

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10.1182/BLOOD-2005-09-3596

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12

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Richard Moriggl

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7284276

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