Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. - Wikidata - awgldk - TriplyDB

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

http://www.wikidata.org/entity/Q33882849

about

Gadd45 stress sensors in malignancy and leukemia The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA Acid ceramidase is upregulated in AML and represents a novel therapeutic target.Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.The essential role of evasion from cell death in cancer.Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression The BCL-2 protein family, BH3-mimetics and cancer therapy.Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.Delving deeper: MCL-1's contributions to normal and cancer biology.Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.Targeting prohibitins induces apoptosis in acute myeloid leukemia cells.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases MYC oncogene in myeloid neoplasias.Programming cancer cells for high expression levels of Mcl1.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation.PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express Aurora kinase A.MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer.Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1 Role of DHX33 in c-Myc-induced cancers.IL-1β inhibits self-renewal capacity of dormant CD34⁺/CD38⁻ acute myelogenous leukemia cells in vitro and in vivo.Targeting apoptosis in acute myeloid leukaemia.Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation.BCL-2 family proteins: changing partners in the dance towards death.Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers.Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.CDK9 inhibitors in acute myeloid leukemia.The expression of Mcl-1 in human cervical cancer and its clinical significance.

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Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

http://www.wikidata.org/entity/Q33882849

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@ast

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@en

type

label

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@ast

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@en

prefLabel

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@ast

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

@en

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Journal of Clinical Investigation

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Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

@en

P2093

Hui Luo

http://www.w3.org/2001/XMLSchema#string

Jacqueline E Payton

http://www.w3.org/2001/XMLSchema#string

Jennifer Cain

http://www.w3.org/2001/XMLSchema#string

Joseph T Opferman

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Michael H Tomasson

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Timothy J Ley

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The Hallmarks of Cancer

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

Small-molecule Bcl-2 antagonists as targeted therapy in oncology

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

c-MYC: more than just a matter of life and death

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

Apoptosis: a link between cancer genetics and chemotherapy.

Distinct thresholds govern Myc's biological output in vivo.

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.

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2109-2118

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10.1172/JCI39964

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6

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120

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2010-05-17T00:00:00Z

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44613594

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20484815

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P921

haploinsufficiency

P932

2877934

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