Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. - Wikidata - awgldk - TriplyDB

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

http://www.wikidata.org/entity/Q33883310

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms Ripped to death DED or alive: assembly and regulation of the death effector domain complexes Protease signalling: the cutting edge Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.A bifunctional allosteric site in the dimer interface of procaspase-3 The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35 A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling The TRAIL of oncogenes to apoptosis.Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells.Modifying caspase-3 activity by altering allosteric networks.Apoptosis as a mechanism for liver disease progression.Turning on caspases with genetics and small molecules Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics.Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma.Neuronal caspase 2 activity and function requires RAIDD, but not PIDD Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Proteasomal regulation of caspase-8 in cancer cell apoptosis The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 Role of caspase-8 in thymus function.Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1.Caspase-8 as a therapeutic target in cancer.Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.Programmed necrosis and autophagy in immune function.Targeting apoptosis in autoimmune hepatitis.

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P2860

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

http://www.wikidata.org/entity/Q33883310

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Inducible dimerization and ind ...... esses in caspase-8 activation.

@ast

Inducible dimerization and ind ...... esses in caspase-8 activation.

@en

type

label

Inducible dimerization and ind ...... esses in caspase-8 activation.

@ast

Inducible dimerization and ind ...... esses in caspase-8 activation.

@en

prefLabel

Inducible dimerization and ind ...... esses in caspase-8 activation.

@ast

Inducible dimerization and ind ...... esses in caspase-8 activation.

@en

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JBC.M109.095083

P1433

Journal of Biological Chemistry

P1476

Inducible dimerization and ind ...... esses in caspase-8 activation.

@en

P2093

Alexandre G Tremblay

http://www.w3.org/2001/XMLSchema#string

Andrew Oberst

http://www.w3.org/2001/XMLSchema#string

Cristina Pop

http://www.w3.org/2001/XMLSchema#string

Guy S Salvesen

http://www.w3.org/2001/XMLSchema#string

Jean-Bernard Denault

http://www.w3.org/2001/XMLSchema#string

Véronique Blais

http://www.w3.org/2001/XMLSchema#string

P2860

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9

Structural basis for the substrate specificity of tobacco etch virus protease

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

Controlled intracellular processing of fusion proteins by TEV protease

The P1' specificity of tobacco etch virus protease

Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency

The apoptosome activates caspase-9 by dimerization

A unified model for apical caspase activation

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16632-16642

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22

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285

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Douglas R. Green

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2010-03-22T00:00:00Z

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20308068

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2878047

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