Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. - Wikidata - awgldk - TriplyDB

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

http://www.wikidata.org/entity/Q33885492

about

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels Presenilins: a novel link between intracellular calcium signaling and lysosomal function?Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.The very many faces of presenilins and the γ-secretase complex.Presenilins and calcium signaling-systems biology to the rescue.Biological function of Presenilin and its role in AD pathogenesis Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease.Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects.Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?Membrane topology of human presenilin-1 in SK-N-SH cells determined by fluorescence correlation spectroscopy and fluorescent energy transfer.Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.The role of Ca2+ signaling in Parkinson's disease.Presenilin adopts the ClC channel fold Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases.Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease

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P2860

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

http://www.wikidata.org/entity/Q33885492

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@ast

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

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type

label

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@ast

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@en

prefLabel

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@ast

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@en

P1433

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P356

JBC.M111.243063

P1433

Journal of Biological Chemistry

P1476

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

@en

P2093

Alexandra Tolia

http://www.w3.org/2001/XMLSchema#string

Charlene Supnet

http://www.w3.org/2001/XMLSchema#string

Ilya Bezprozvanny

http://www.w3.org/2001/XMLSchema#string

Katrien Horré

http://www.w3.org/2001/XMLSchema#string

Omar Nelson

http://www.w3.org/2001/XMLSchema#string

P2860

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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22339-22347

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scholarly article

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10.1074/JBC.M111.243063

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25

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286

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Bart De Strooper

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21531718

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3121381

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