Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
about
The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaksHuman SAD1 kinase is involved in UV-induced DNA damage checkpoint functionCoordination of DNA damage responses via the Smc5/Smc6 complexCAP37 activation of PKC promotes human corneal epithelial cell chemotaxisDNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemHus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damageAnalysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointS-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombeGerminating fission yeast spores delay in G1 in response to UV irradiationTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyReplication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast.WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients.Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint functionCell cycle checkpoint in cancer: a therapeutically targetable double-edged swordThe Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01Checkpoint kinase 1 in DNA damage response and cell cycle regulationThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designRoles of Chk1 in cell biology and cancer therapyc-Fos/activator protein-1 transactivates wee1 kinase at G(1)/S to inhibit premature mitosis in antigen-specific Th1 cells.Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanismThe Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatinWee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomasCloning and characterization of liver-specific isoform of Chk1 gene from ratEpstein-Barr virus-encoded latent membrane protein 1 impairs G2 checkpoint in human nasopharyngeal epithelial cells through defective Chk1 activationChk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.Importance of a C-terminal conserved region of Chk1 for checkpoint function.Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.Fission yeast Rad17 associates with chromatin in response to aberrant genomic structuresChk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.Rad18 is required for DNA repair and checkpoint responses in fission yeast.Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1Control of Swe1p degradation by the morphogenesis checkpoint.Positive regulation of Wee1 by Chk1 and 14-3-3 proteins.Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR.DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.
P2860
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P2860
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@ast
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@en
type
label
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@ast
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@en
prefLabel
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@ast
Chk1 is a wee1 kinase in the G ...... g cdc2 by Y15 phosphorylation.
@en
P2093
P2860
P356
P1433
P1476
Chk1 is a wee1 kinase in the G ...... ng cdc2 by Y15 phosphorylation
@en
P2093
J M Raleigh
M J O'Connell
P2860
P304
P356
10.1093/EMBOJ/16.3.545
P407
P577
1997-02-01T00:00:00Z