Targeted expression of MYCN causes neuroblastoma in transgenic mice. - Wikidata - awgldk - TriplyDB

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

http://www.wikidata.org/entity/Q33886720

about

NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells Drugging MYCN through an allosteric transition in Aurora kinase A SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma Identification of ALK as a major familial neuroblastoma predisposition gene The Skin as an Early Expression of Malignancies in the Neonatal Age: A Review of the Literature and a Case Series Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches Small-molecule inhibitors of the Myc oncoprotein Involvement of midkine in neuroblastoma tumourigenesis Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.The zebrafish as a model for studying neuroblastoma Focal DNA copy number changes in neuroblastoma target MYCN regulated genes Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination Molecular pathogenesis of peripheral neuroblastic tumors In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis.N-MYC regulates focal adhesion kinase expression in human neuroblastoma.Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status.Mutations in PIK3CA are infrequent in neuroblastoma.Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines.Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse.Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis.Upstream ORF affects MYCN translation depending on exon 1b alternative splicing Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.MYC oncogenes and human neoplastic disease.MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma

P2860

Q21092404-A714D594-E558-42BE-87E2-42E000351CA4 Q24296639-7DE43D55-E22B-498D-83F1-0771877BFA85 Q24297046-0458C4B3-3687-4200-BACD-F7FEEFE55C89 Q24303381-EA2122B1-2E87-4DB1-A631-D82F33ED9CF3 Q24307488-B303A39F-EEF5-4AEC-98F3-2E37DBA49EEF Q24322761-EC3DCF2A-60E0-4420-8E00-E56C82E5471A Q24655923-5A527F07-A683-4901-ABA1-78DECF44DF1D Q26769681-AEE73D6C-691A-470B-9D9A-F877D23FDF98 Q26770306-2520A6D5-7E5D-4CDA-BDC0-C57620637262 Q26825652-6919119B-B6E1-498D-8F5F-D308A2F56E3F Q27025648-0E98AE86-BA1D-44EA-A9FB-D95132D9CB22 Q27026748-FA9F3A0C-3D36-49CB-8055-8537F236F3E0 Q27853237-6C070287-4E2A-49E8-A92E-47394C48CFDD Q28070309-031AE5C4-E9E4-47E2-9220-641C860C4EFF Q28115604-3E4B197B-55F1-4F31-B522-7A419A316F9F Q28117269-8561479F-418A-4449-BE93-58B2D439F603 Q28118450-F4DB4724-53B4-435F-AE55-C5D1232ED6BC Q28271405-ED1FE2BB-AD2F-4C28-88FF-485EA19DD7A8 Q28364316-01A8B844-CFBE-4964-82BE-86A8F9DC10B5 Q28377114-F19E9203-C24A-47BB-A053-B40C34114EF7 Q28538332-9AEFAEA7-5185-446D-A278-AB18F1D1D6C7 Q28540575-AB913E95-8138-4FF0-B910-5BE60F7F1BAF Q28817295-3D2C7B09-AD67-4B8C-B1C3-5159DEF89907 Q30239861-C94E6809-23FB-4BB2-ACB9-80FB81DD6AEA Q30541198-91931BA5-7FB4-48D9-913F-C3675ACB8260 Q30983520-34E12A6B-A4B2-43C6-8EB8-242EC20833D9 Q31814799-F4BC42B0-91C2-41B7-A1E5-16FCA4778591 Q33183408-A9C1AEED-78DF-4546-B981-17A081E5B90A Q33248957-C8CA9209-ABFC-49FA-ABF6-7BCF2ED000A9 Q33258311-6F2C4382-F5D0-4688-BE4B-425B5674FCDF Q33335885-28519B27-FB88-4E55-94A0-A86A3046CBAB Q33369231-9101C8A8-B3E3-49C9-9A9C-0294085672D6 Q33490314-400171D0-246E-433A-8287-FFC3244EED41 Q33500160-65C77087-37D0-4CE0-B523-6BD9D8C474D7 Q33510925-4247BECE-9A3A-48C2-AF51-3F5B1B9D8D0F Q33519157-29BAEF23-C392-432E-866F-88E944F0204C Q33578581-F200C0F4-A916-4571-B494-2628B8DA3B83 Q33643120-A93D89F3-C6BB-4B20-9066-B2E3CDE6BB49 Q33667340-E2E73F40-30E3-4BAC-A5DD-6CB78D3CF564 Q33667823-827005ED-081B-45DF-82D9-F14A31D0AB70

P2860

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

http://www.wikidata.org/entity/Q33886720

description

1997 nî lūn-bûn

@nan

1997 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի հունիսին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年学术文章

@wuu

1997年学术文章

@zh-cn

1997年学术文章

@zh-hans

1997年学术文章

@zh-my

1997年学术文章

@zh-sg

1997年學術文章

@yue

name

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@ast

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@en

type

label

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@ast

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@en

prefLabel

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@ast

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@en

P1433

Q33886720-F578DBB0-3A86-4F09-A8BB-0E1E0D6477EC

P1476

Q33886720-732C364C-8084-4D62-B959-734B83A08BDA

P2093

Q33886720-4797CD99-79E8-4FB6-91D4-46738631702F

Q33886720-4BFF4D9F-3FCC-4468-A4DB-4EB3D19A6BD8

Q33886720-5942DE2D-131A-4615-B595-6E2CF6D9CC42

Q33886720-EC3A739F-BCEC-4B03-9A29-EFC147791AA6

Q33886720-F69312EB-3AE0-4429-9530-C90C6FE01E69

P2860

Q33886720-1FFEC47A-E4DA-4EF5-BFEA-02078C045959

Q33886720-20D71F7D-AA0D-4067-8CDC-DA0E37D7D6D2

Q33886720-2B1D86BC-205B-4C38-9BBA-AD31012694F6

Q33886720-2B6E1923-E57E-4C6B-B627-F0F418884108

Q33886720-33E4EE07-A3B9-4145-B171-7FCE9FABCCE2

Q33886720-397711D6-B9BE-4F35-A0EE-6725A74FF64D

Q33886720-41F94390-62F4-4760-87EA-B7328A2514E4

Q33886720-4DEA61D2-4D10-4537-A82D-406EDA969FA7

Q33886720-4FE9C002-9FED-40F0-A380-38D222F5A315

Q33886720-60BE8460-083C-441D-AD22-1C0721882073

P304

Q33886720-B2EE75F5-0366-45A6-9F6A-0986E48CA919

P31

Q33886720-BD26C97E-0EE6-4EAE-B337-3A49D134A6E7

P356

Q33886720-ED2C3944-4639-4E52-948C-652A90100ED2

P407

Q33886720-498C4BDE-3DE2-40C2-B4CD-F019723849E0

P433

Q33886720-C10C9862-5A68-47C3-88E4-D2444A7BA2C1

P478

Q33886720-A6DF1779-2366-467D-8C38-E3CDF90181C9

P577

Q33886720-EC28A9BA-3194-4333-980A-AFA9E606432A

P5875

Q33886720-38BC4C53-C7ED-4355-A102-7DBF0B27837A

P698

Q33886720-B3504C65-E274-42CA-961B-63B883CE2F03

P932

Q33886720-0BB622E5-8A64-4F7B-B016-220C72F6E69C

P356

P1433

The EMBO Journal

P1476

Targeted expression of MYCN causes neuroblastoma in transgenic mice.

@en

P2093

B G Feuerstein

http://www.w3.org/2001/XMLSchema#string

G Mohapatra

http://www.w3.org/2001/XMLSchema#string

J M Bishop

http://www.w3.org/2001/XMLSchema#string

K Aldape

http://www.w3.org/2001/XMLSchema#string

W A Weiss

http://www.w3.org/2001/XMLSchema#string

P2860

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA

Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras

A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3

Lessons from hereditary colorectal cancer

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Effects of an Rb mutation in the mouse

Neuroblastoma: a clinical challenge and biologic puzzle.

P304

2985-2995

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/EMBOJ/16.11.2985

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

16

http://www.w3.org/2001/XMLSchema#string

P577

1997-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14004118

http://www.w3.org/2001/XMLSchema#string

P698

9214616

http://www.w3.org/2001/XMLSchema#string

P932

1169917

http://www.w3.org/2001/XMLSchema#string