ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.
about
Ku is associated with the telomere in mammalsTANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpressionInteraction of the HPV E7 proteins with the pCAF acetyltransferaseING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylationControl of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Cellular Senescence:Ex Vivop53-Dependent Asymmetric Cell KineticsPoly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53ATM Kinase Is Required for Telomere Elongation in Mouse and Human CellsInhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ationPoly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functionsPoly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcriptionActivation and activities of the p53 tumour suppressor proteinGenomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient miceDepletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in miceNiacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cellsPoly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsSenescent cells communicate via intercellular protein transfer.The ACTCellerate initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives.Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.The E7 oncoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF).Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Telomeres: protecting chromosomes against genome instabilityIncreased expression of cyclin D2 during multiple states of growth arrest in primary and established cellsAlternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?Physical and functional interaction between p53 and the Werner's syndrome protein.HTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells.Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.Atm inactivation results in aberrant telomere clustering during meiotic prophase.Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatmentDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressRole of p14(ARF) in replicative and induced senescence of human fibroblasts.Role of oxidatively induced DNA lesions in human pathogenesisConversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes.Regulation of cellular senescence by p53.The essence of senescence.Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+).
P2860
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P2860
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@ast
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@en
type
label
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@ast
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@en
prefLabel
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@ast
ATM-dependent telomere loss in ...... g poly(ADP-ribose) polymerase.
@en
P2093
P2860
P356
P1433
P1476
ATM-dependent telomere loss in ...... ng poly(ADP-ribose) polymerase
@en
P2093
Allsopp RC
Benchimol S
Davison TS
Poirier GG
P2860
P304
P356
10.1093/EMBOJ/16.19.6018
P407
P577
1997-10-01T00:00:00Z