Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
about
AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14)New insight into the molecular mechanisms of MLL-associated leukemiaMLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein functionThe leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusionsProteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationThe elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesisMLL and CREB bind cooperatively to the nuclear coactivator CREB-binding proteinHuman LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expressionModulation of cell cycle by graded expression of MLL-AF4 fusion oncoproteinDisruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.Structure of AF3p21, a new member of mixed lineage leukemia (MLL) fusion partner proteins-implication for MLL-induced leukemogenesis.GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24).Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesisZebrafish mll gene is essential for hematopoiesis.MLL fusion partners AF4 and AF9 interact at subnuclear foci.Common themes in the pathogenesis of acute myeloid leukemia.Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.Genetic and molecular analysis of region 88E9;88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias.Chromatin modification, leukaemia and implications for therapy.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.MLL fusions: pathways to leukemiaThe pathogenesis of mixed-lineage leukemia.The MLL partial tandem duplication in acute myeloid leukaemia.TET1 plays an essential oncogenic role in MLL-rearranged leukemiaReview: genetic models of acute myeloid leukaemia.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Mechanisms of mixed-lineage leukemia.The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.FOXO transcription factors in cancer development and therapy.Transcriptional activation is a key function encoded by MLL fusion partners.FOXO Signaling Pathways as Therapeutic Targets in Cancer.Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2.Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.
P2860
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P2860
Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@ast
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@en
type
label
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@ast
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@en
prefLabel
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@ast
Tumorigenesis in mice with a f ...... l and the bacterial lacZ gene.
@en
P2093
P2860
P356
P1433
P1476
Tumorigenesis in mice with a f ...... ll and the bacterial lacZ gene
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.5.843
P407
P577
2000-03-01T00:00:00Z