NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.
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Highlights on distinctive structural and functional properties of HTLV Tax proteinsHTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZMultifaceted functions and roles of HBZ in HTLV-1 pathogenesisThe Role of HBZ in HTLV-1-Induced OncogenesisHow does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and PersistenceRNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells.Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines.Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex.KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.Identification and characterization of HTLV-1 HBZ post-translational modifications.HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factorsHow the DNA damage response determines the fate of HTLV-1 Tax-expressing cells.Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion.Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma.Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cellsSelective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.The autophagy molecule Beclin 1 maintains persistent activity of NF-κB and Stat3 in HTLV-1-transformed T lymphocytes.Foxp3-dependent transformation of human primary CD4+ T lymphocytes by the retroviral protein taxFACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral LatencyHTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysComplex role of microRNAs in HTLV-1 infections.PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival.Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.A new look at T cell receptor signaling to nuclear factor-κBFunctional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesisThe shrimp IKK-NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus to facilitate viral gene expression.Differential transforming activity of the retroviral Tax oncoproteins in human T lymphocytes.HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signalingNF-κB inhibition facilitates the establishment of cell lines that chronically produce human T-lymphotropic virus type 1 viral particlesHTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells.Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2.A Luciferase Functional Quantitative Assay for Measuring NF-ĸB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins.
P2860
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P2860
NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@ast
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@en
type
label
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@ast
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@en
prefLabel
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@ast
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@en
P2093
P2860
P1433
P1476
NF-κB hyper-activation by HTLV ...... viral anti-sense protein HBZ.
@en
P2093
Chou-Zen Giam
Hsiu-Ming Shih
Huijun Zhi
Liangpeng Yang
Yik-Khuan Ho
Yu-Liang Kuo
P2860
P304
P356
10.1371/JOURNAL.PPAT.1002025
P577
2011-04-28T00:00:00Z