Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
about
Viruses associated with human cancerHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsNF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery.Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor virusesActivation of the anaphase promoting complex by HTLV-1 tax leads to senescence.Recent advances in understanding NF-kappaB regulation.Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1.Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisNF-κB and cancer: a paradigm of Yin-Yang.Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promotersHTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesisProapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway.Novel Phosphorylations of IKKγ/NEMO.HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysPDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradationNF-κB as a target for oncogenic viruses.Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.New insight into the oncogenic mechanism of the retroviral oncoprotein Tax.The role of the IKK complex in viral infections.Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activationHeptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax.Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.Regulation of NF-kappa B2 p100 processing by its cis-acting domain.Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms.Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100.Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.
P2860
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P2860
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@ast
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@en
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@nl
type
label
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@ast
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@en
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@nl
prefLabel
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@ast
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@en
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@nl
P2860
P3181
P356
P1433
P1476
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
@en
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1203894
P407
P577
2000-10-26T00:00:00Z
P5875
P6179
1048672151