Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
about
High mobility group protein-1 (HMG-1) is a unique activator of p53The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.Crystal structure of a p53 core tetramer bound to DNACrystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled TetramerStructures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsp53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum ConceptNoncanonical DNA motifs as transactivation targets by wild type and mutant p53Cooperativity dominates the genomic organization of p53-response elements: a mechanistic viewp53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element.Multimerization-cyclization of DNA fragments as a method of conformational analysis.Gapped DNA and cyclization of short DNA fragments.The role of tetramerization in p53 function.Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNACharacterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect.Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting.p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactions.The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.Transcriptional regulation by p53.Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells.Structure of the p53 core domain dimer bound to DNA.DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element.Full-length p53 tetramer bound to DNA and its quaternary dynamics.Recognition of Local DNA Structures by p53 Protein.p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks.An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes.Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination.Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein.Replication of damaged DNA in vitro is blocked by p53.Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.NAD+ modulates p53 DNA binding specificity and function.p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation.A fluid salt-bridging cluster and the stabilization of p53.Distinct distal and proximal p53-binding sites in the MCK promoter govern the transcriptional response to p53.Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53.How p53 binds DNA as a tetramer.Conformational detection of p53's oligomeric state by FlAsH Fluorescence.
P2860
Q24311393-7C0887A8-715B-494B-A34D-813862C05194Q24533291-7BF6FA5B-8952-4EA5-BC4D-C076751AF8D6Q27652740-5FB4590E-512E-4CA9-B954-E96D66C816C4Q27659877-299DA744-A9A9-43A1-8292-AA553D70712CQ27667425-90C6CCB9-656A-414A-AFB4-28E62DD7A4A9Q28079390-94583EB9-FFB1-4D5B-9AF1-1109162EE9C7Q33361623-CDB48599-2643-4C1C-842C-033C52747182Q33486476-6D814E69-798B-4561-BA14-3D0476411ED5Q33569713-CBEC412C-E39A-4DD5-8D3A-545E070B8EF6Q34174353-879A1335-43EC-4BFC-910A-C6955FDA2685Q34190685-63A606A4-3F8D-4E38-9A56-E1F09FA7BE42Q34290217-728A2A14-9011-4CF9-B786-8DED2F369483Q34490497-B916E18A-8FB9-4C6E-AAF1-9C77DB503C67Q34961997-2BE1D8B0-6872-4973-8E1C-867482B1F7A9Q35099489-532EE6A4-C00E-4B36-8D49-41E429FB7054Q35205701-7584175F-4C58-444C-AEC4-24727A78817CQ37161582-FB2E7416-0893-4540-B42E-D19D4C0D8F98Q37370175-72FD927B-478F-407E-9EDB-53175D97D9FFQ37596345-47A97173-32D7-4974-84E0-D349A8489293Q37777267-1353C770-1233-4F3F-9756-54FBC0F2F8EFQ38300890-74FB64A2-6DE2-497D-8719-C06B444BC5E7Q38313002-BCBD8564-2766-43B4-9A8E-65CC12DF757FQ38345163-5FD02EC0-851B-4233-BFA3-8302C2B0F7E2Q38345165-97443DDF-BE69-43F8-9256-5D3C11E84DADQ38820037-69BCFA34-521D-4795-8DBC-1C0324ECEDCBQ38956978-B9E298F7-9701-49C5-B25F-649F73D633C6Q39111656-67235BFD-7834-4AE4-994B-A0EBC2696C30Q39448525-ADAF7B7C-E277-4741-B7AF-F5AA14107FFAQ39575932-66EC9CE6-07C7-44E9-A97B-46484D4873ADQ39675422-5AF49BD8-630F-4B95-A250-B2E750023A8AQ39792211-1C85F65E-C505-4D7E-8671-675B932D2493Q40020159-2E26B0FB-5A2A-4307-A529-EB3A2A6B82EEQ40175015-421E8319-E0FA-4EA6-8B7C-EFAD4D863A80Q40291911-E4AB1CF7-30E0-48D3-99E8-FD215D5F4D69Q40738842-7F9DA17D-18E7-4BBF-A6A5-256F0E7DDD2DQ40976711-FA29B501-C77B-4476-B641-287FF883213EQ41116184-0FB51022-FA31-44DC-A1E0-D9F310736888Q41504798-487D68C9-D543-4274-8448-A5BF6690E872Q41787604-3EACC0B4-175E-4842-A192-09456395A5AFQ41975268-6C5B5DC2-78BD-45E2-9EC8-F476BEE6FE99
P2860
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@ast
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@en
type
label
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@ast
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@en
prefLabel
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@ast
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@en
P2093
P2860
P356
P1476
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
@en
P2093
A M Gronenborn
H Sakamoto
P Balagurumoorthy
P2860
P304
P356
10.1073/PNAS.92.19.8591
P407
P577
1995-09-01T00:00:00Z