Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53 - Wikidata - awgldk - TriplyDB

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

http://www.wikidata.org/entity/Q35205701

about

The transcription factor p53: not a repressor, solely an activator A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway Smoking, p53 mutation, and lung cancer Another fork in the road--life or death decisions by the tumour suppressor p53 AMID is a p53-inducible gene downregulated in tumors Noncanonical DNA motifs as transactivation targets by wild type and mutant p53 Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73.USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome.Mechanisms of regulatory diversity within the p53 transcriptional network.A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage The complex interactions of p53 with target DNA: we learn as we go.Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival.Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription.The p53 tumor suppressor protein regulates hematopoietic stem cell fate.Battle against cancer: an everlasting saga of p53.Transcriptional repression by p53 through direct binding to a novel DNA element.Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex.p53 responsive elements in human retrotransposons.A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites.Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences.New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression.Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function.Transcriptional activation of the MUC2 gene by p53.P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.A single mutant, A276S of p53, turns the switch to apoptosis.Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.Differential regulation of p53 target genes: it's (core promoter) elementary.

P2860

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P2860

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

http://www.wikidata.org/entity/Q35205701

description

1998 nî lūn-bûn

@nan

1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հուլիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Identification of a novel clas ...... e tumor suppressor protein p53

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Identification of a novel clas ...... e tumor suppressor protein p53

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type

label

Identification of a novel clas ...... e tumor suppressor protein p53

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Identification of a novel clas ...... e tumor suppressor protein p53

@en

prefLabel

Identification of a novel clas ...... e tumor suppressor protein p53

@ast

Identification of a novel clas ...... e tumor suppressor protein p53

@en

P1433

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P2860

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Genes & Development

P1476

Identification of a novel clas ...... e tumor suppressor protein p53

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P2093

J J Manfredi

http://www.w3.org/2001/XMLSchema#string

K Zhao

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L Resnick-Silverman

http://www.w3.org/2001/XMLSchema#string

M Maurer

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S St Clair

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P2860

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

Definition of a consensus binding site for p53

Induction of the growth inhibitor IGF-binding protein 3 by p53

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

p53: puzzle and paradigm

Radiation-induced cell cycle arrest compromised by p21 deficiency

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

P304

2102-2107

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scholarly article

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10.1101/GAD.12.14.2102

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14

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12

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1998-07-01T00:00:00Z

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9679054

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317007

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