about
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationTotal synthesis of bryostatin 16 using atom-economical and chemoselective approachesCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroEfficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityTotal synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreEnantioselective Alcohol C-H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis.Total synthesis of bryostatin 1Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation.Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyransComputer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopySynthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Total synthesis of bryostatins: the development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit.Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment.Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ringToward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.Sequential Ru-Pd catalysis: a two-catalyst one-pot protocol for the synthesis of N- and O-heterocycles.Evolution of multi-component anion relay chemistry (ARC): construction of architecturally complex natural and unnatural products.Neurotrophic natural products: chemistry and biology.Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiencyPolyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.Synthesis of a ring-expanded bryostatin analogue.Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.A new construction of 2-alkoxypyrans by an acylation-reductive cyclization sequence.Concise synthesis of the bryostatin A-ring via consecutive C-C bond forming transfer hydrogenations.Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.
P2860
Q24599839-0EAAEE32-5DD3-477C-9607-D82C1F6CDE9FQ24607710-4C504295-7B74-4D1F-9684-236CD8359533Q24649951-CA7E7565-FE5A-4784-AA6B-8EF86D59ADC7Q26772873-47B05D0F-2120-4A5C-8988-7F6D925E740EQ30558754-598B0F9C-AF86-4672-97D6-28BA55975111Q33331435-4918282F-CCD8-4036-9D5C-174873221C49Q33736184-0BDD4615-83B0-4340-8C3F-9AA4552C86B3Q33849709-B627CB6B-0802-4F7F-9C0A-007B1C584960Q34187866-F5FE6C19-F0A8-441E-912A-7D80136EE5F2Q34282542-D55AB847-56B1-42DF-B578-93BC4C1F2A06Q34282624-D8C4CB11-298C-4882-B663-C0C4B9354A80Q34523499-E6E3EDFA-2D11-4B02-AF9E-D88D9A6FDC81Q34538229-6AC12A67-4A42-4C50-B7E2-CA812328AEBFQ34591418-B527E9DC-26CA-4760-9ACF-8DA20A221BF7Q34686860-B4553181-8195-481A-88BC-F562DA167E5EQ34686885-AE346801-1FBD-4CF5-81BF-4C6824D188F4Q35100672-B0A730D0-5055-471E-B299-61490D601D4AQ35132573-2457A8A4-46AA-4BD8-A70F-A06CCEE2EBB5Q35511561-BB912B20-19BD-4DDB-BB33-737023CFE210Q35741019-21DCA732-EE06-4EC3-9BF6-91088F8900C5Q35799776-E02BF836-C5FE-4E96-9BBA-4F659E0679F5Q36220354-969C39C0-F5C3-4DBF-86F2-E4E1A028EF5BQ36452817-E23C12D8-6927-4A2D-86ED-E44E6B6DC754Q36452840-D2B32CBF-79C1-4828-A1A8-D653A6CD2BCEQ36510954-3BE0ECE8-F3A0-46EE-81E8-F6F82AF1DF94Q36837850-7EFCE8D1-A4C8-4B62-8A6B-5D7B264D6E66Q37095319-FD6B8276-4203-4B78-BEC2-60F22AC56539Q37309973-C83E2958-3037-41D0-B1FA-F155B91E7DF6Q37333806-30C75D6A-C044-4682-93CD-07C5F244599CQ37623342-A994703F-FD7B-4A86-B837-842DF15A9171Q37660116-5102DFC2-E8E0-4189-AE84-F0868F8A4950Q38186988-029802A4-142A-405F-9C7F-D5FC4387E391Q39967020-B0A77B51-29D4-4AE7-80CF-868CB253560BQ40174456-8E73A108-C6E1-4A41-8CB7-6F87F1DBEE4DQ40256582-813B5409-7575-45DD-900D-C05CD44413F5Q42135531-89B1D975-29BD-4B49-A435-243FA3521F95Q42141736-A22E5F57-69DA-4D54-BC35-CD10076F5573Q43068920-D59C2BF6-D782-4EAB-92F6-DF57B506E2ABQ47614932-0AD8CC63-4C6E-46A9-B810-DEB76ED09C9E
P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Total Synthesis of Bryostatin 3
@ast
Total Synthesis of Bryostatin 3
@en
type
label
Total Synthesis of Bryostatin 3
@ast
Total Synthesis of Bryostatin 3
@en
prefLabel
Total Synthesis of Bryostatin 3
@ast
Total Synthesis of Bryostatin 3
@en
P2093
P1433
P1476
Total Synthesis of Bryostatin 3
@en
P2093
P304
P356
10.1002/1521-3773(20000703)39:13<2290::AID-ANIE2290>3.3.CO;2-Y
P577
2000-07-01T00:00:00Z