Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
about
Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expressionDeletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell developmentCux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activatorInitiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assemblySynapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleA novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.A dominant-negative transgene defines a role for p56lck in thymopoiesis.Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in transTCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.Elucidation of IgH intronic enhancer functions via germ-line deletionRegulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ.Epigenetic control of recombination in the immune systemT cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate.Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segmentsDynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulinsp70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain geneResolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrowHeavy chain variable (VH) region diversity generated by VH gene replacement in the progeny of a single precursor cell transformed with a temperature-sensitive mutant of Abelson murine leukemia virusImmunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication.Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage.Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cellsRegulation of T cell receptor delta gene rearrangement by c-Myb.Domains of the TCR beta-chain required for early thymocyte development.Positive and negative regulation of V(D)J recombination by the E2A proteins.The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrateEnhancer control of local accessibility to V(D)J recombinase.Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptorBiased T-cell receptor delta element recombination in scid thymocytes.Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.A novel POU domain protein which binds to the T-cell receptor beta enhancer.Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.
P2860
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P2860
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
description
1990 nî lūn-bûn
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1990 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1990年の論文
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1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
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name
Separate elements control DJ a ...... sgenic recombination substrate
@ast
Separate elements control DJ a ...... sgenic recombination substrate
@en
type
label
Separate elements control DJ a ...... sgenic recombination substrate
@ast
Separate elements control DJ a ...... sgenic recombination substrate
@en
prefLabel
Separate elements control DJ a ...... sgenic recombination substrate
@ast
Separate elements control DJ a ...... sgenic recombination substrate
@en
P2093
P2860
P1433
P1476
Separate elements control DJ a ...... sgenic recombination substrate
@en
P2093
A J Furley
F Costantini
T K Blackwell
P2860
P304
P407
P577
1990-01-01T00:00:00Z