Elucidation of IgH intronic enhancer functions via germ-line deletion - Wikidata - awgldk - TriplyDB

Elucidation of IgH intronic enhancer functions via germ-line deletion

Elucidation of IgH intronic enhancer functions via germ-line deletion

http://www.wikidata.org/entity/Q34063681

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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.Long-Range Regulation of V(D)J Recombination Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies A coming-of-age story: activation-induced cytidine deaminase turns 10.Epigenetic control of immunity Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Generation and repair of AID-initiated DNA lesions in B lymphocytes.The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus Immunoglobulin G locus events in soft tissue sarcoma cell lines.AID and somatic hypermutation.Epigenetic control of recombination in the immune system AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Targeting of somatic hypermutation.Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.Targeting the oncogene B lymphoma deregulator IgH 3' regulatory region does not impede the in vivo inflammatory response in mice.Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination Yin Yang 1 is a critical regulator of B-cell development Enhancers located in heavy chain regulatory region (hs3a, hs1,2, hs3b, and hs4) are dispensable for diversity of VDJ recombination Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation Developmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus.The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.

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Elucidation of IgH intronic enhancer functions via germ-line deletion

http://www.wikidata.org/entity/Q34063681

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Elucidation of IgH intronic enhancer functions via germ-line deletion

@ast

Elucidation of IgH intronic enhancer functions via germ-line deletion

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Elucidation of IgH intronic enhancer functions via germ-line deletion

@nl

type

label

Elucidation of IgH intronic enhancer functions via germ-line deletion

@ast

Elucidation of IgH intronic enhancer functions via germ-line deletion

@en

Elucidation of IgH intronic enhancer functions via germ-line deletion

@nl

prefLabel

Elucidation of IgH intronic enhancer functions via germ-line deletion

@ast

Elucidation of IgH intronic enhancer functions via germ-line deletion

@en

Elucidation of IgH intronic enhancer functions via germ-line deletion

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Elucidation of IgH intronic enhancer functions via germ-line deletion

@en

P2093

Craig H Bassing

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

http://www.w3.org/2001/XMLSchema#string

Heikyung Suh

http://www.w3.org/2001/XMLSchema#string

Thomas Perlot

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P2860

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate

The 3' IgH regulatory region: a complex structure in a search for a function.

Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.

The generation of antibody diversity through somatic hypermutation and class switch recombination.

Unraveling V(D)J recombination; insights into gene regulation.

Mechanism and control of class-switch recombination.

The mechanism and regulation of chromosomal V(D)J recombination.

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

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14362-14367

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