LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
about
In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson's Disease Pathology.The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.The Enzymatic Core of the Parkinson’s Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brainLRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
P2860
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
description
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name
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@en
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@nl
type
label
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@en
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@nl
prefLabel
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@en
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@nl
P2093
P2860
P356
P1476
LRRK2 phosphorylates membrane- ...... nt to the trans-Golgi network.
@en
P2093
Alexandra Beilina
Andrew B West
Asa Abeliovich
Nicole Bryant
Ravindran Kumaran
Zhiyong Liu
P2860
P304
P356
10.1093/HMG/DDX410
P577
2017-11-21T00:00:00Z