Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.
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Mouse models of polyglutamine diseases: review and data table. Part IMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's DiseaseDifferential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's Disease.Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington diseaseForebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington's Disease Mice.Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease.Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington's DiseaseStriatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease.Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's disease model miceMultiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models.Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.Partial Amelioration of Peripheral and Central Symptoms of Huntington's Disease via Modulation of Lipid Metabolism.Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.Corticostriatal synaptic adaptations in Huntington's diseaseDevelopment of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington's Disease Mouse Model.Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease.Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease.Disrupted striatal neuron inputs and outputs in Huntington's disease.Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.
P2860
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P2860
Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Alterations in striatal synapt ...... odels of Huntington's disease.
@ast
Alterations in striatal synapt ...... odels of Huntington's disease.
@en
type
label
Alterations in striatal synapt ...... odels of Huntington's disease.
@ast
Alterations in striatal synapt ...... odels of Huntington's disease.
@en
prefLabel
Alterations in striatal synapt ...... odels of Huntington's disease.
@ast
Alterations in striatal synapt ...... odels of Huntington's disease.
@en
P2093
P2860
P356
P1433
P1476
Alterations in striatal synapt ...... odels of Huntington's disease.
@en
P2093
Carlos Cepeda
Damian M Cummings
Michael S Levine
P2860
P304
P356
10.1042/AN20100007
P577
2010-06-18T00:00:00Z