Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
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Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsMutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's diseaseCorticostriatal Dysfunction in Huntington's Disease: The BasicsMouse models of polyglutamine diseases: review and data table. Part IThe Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicityTrendelenburg-Like Gait, Instability and Altered Step Patterns in a Mouse Model for Limb Girdle Muscular Dystrophy 2iA broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.Reversal learning and associative memory impairments in a BACHD rat model for Huntington diseaseThe Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesiImprovement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.Mouse models of Huntington's disease and methodological considerations for therapeutic trials.Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease.Automated quantitative gait analysis in animal models of movement disorders.Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.Quantification of gait parameters in freely walking rodents.Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and AmpakinesUbiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissuesAlterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.Early autophagic response in a novel knock-in model of Huntington diseaseSmall-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's diseaseDifferential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 miceComprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep.Reduced expression of conditioned fear in the R6/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex.Chromosome substitution strain assessment of a Huntington's disease modifier locusHtt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease.Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward.Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease.Abnormal burst patterns of single neurons recorded in the substantia nigra reticulata of behaving 140 CAG Huntington's disease miceStriatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease.Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice.
P2860
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P2860
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Extensive early motor and non- ...... k-in Huntington's disease mice
@ast
Extensive early motor and non- ...... k-in Huntington's disease mice
@en
type
label
Extensive early motor and non- ...... k-in Huntington's disease mice
@ast
Extensive early motor and non- ...... k-in Huntington's disease mice
@en
prefLabel
Extensive early motor and non- ...... k-in Huntington's disease mice
@ast
Extensive early motor and non- ...... k-in Huntington's disease mice
@en
P2093
P2860
P1433
P1476
Extensive early motor and non- ...... k-in Huntington's disease mice
@en
P2093
A Kosmalska
M S Levine
M-F Chesselet
P2860
P304
P356
10.1016/J.NEUROSCIENCE.2008.08.041
P407
P577
2008-08-27T00:00:00Z