Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.
about
Identification of direct protein targets of small moleculesYeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnologyEnergetics-based discovery of protein-ligand interactions on a proteomic scale.StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.Simplified proteomics approach to discover protein-ligand interactions.Target deconvolution techniques in modern phenotypic profiling.Target identification of small molecules based on chemical biology approaches.Target identification for small bioactive molecules: finding the needle in the haystack.Isobaric labeling-based relative quantification in shotgun proteomics.Structure-based systems biology for analyzing off-target bindingStable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactionsThermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach.Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery.Global analysis of protein folding thermodynamics for disease state characterizationGenetic and proteomic approaches to identify cancer drug targets.Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.Identification of protein binding partners of small molecules using label-free methods.Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells.Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.Exploiting conformational ensembles in modeling protein-protein interactions on the proteome scale.Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidationFalse-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.Affinity purification in target identification: the specificity challenge.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis.Advances in identification and validation of protein targets of natural products without chemical modification.Emerging Methods in Chemoproteomics with Relevance to Drug Discovery.Effects of hesperidin, a flavanone glycoside interaction on the conformation, stability, and aggregation of lysozyme: multispectroscopic and molecular dynamic simulation studies?Effects of 2-amino-8-hydroxyquinoline interaction on the conformation of physiological isomers of human serum albumin.Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome.Mass spectrometry methods to study protein-metabolite interactions.Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach.Limited proteolysis in porous membrane reactors containing immobilized trypsin.Label-free technologies for target identification and validation
P2860
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P2860
Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Quantitative proteomics approa ...... rotein stability measurements.
@ast
Quantitative proteomics approa ...... rotein stability measurements.
@en
type
label
Quantitative proteomics approa ...... rotein stability measurements.
@ast
Quantitative proteomics approa ...... rotein stability measurements.
@en
prefLabel
Quantitative proteomics approa ...... rotein stability measurements.
@ast
Quantitative proteomics approa ...... rotein stability measurements.
@en
P2093
P2860
P356
P1476
Quantitative proteomics approa ...... protein stability measurements
@en
P2093
Graham M West
John R Yates
Michael C Fitzgerald
Sung Kyu Park
Xuemei Han
P2860
P304
P356
10.1073/PNAS.1000148107
P407
P577
2010-05-03T00:00:00Z