N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
about
The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule PathwayBiophysical characterization of α-synuclein and its controversial structureExploring the accessible conformations of N-terminal acetylated α-synucleinStructure and mechanism of non-histone protein acetyltransferase enzymesN-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsStructure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific AcetylationMolecular basis for N-terminal acetylation by the heterodimeric NatA complexImplications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal orthologStructural basis for substrate-specific acetylation of Nα-acetyltransferase Ard1 from Sulfolobus solfataricusCatalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionalityMultiple Conformations of the Loop Region Confers Heat-Resistance on SsArd1, a Thermophilic NatAN-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiaeN-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo.Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein foldingExpression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylationBiochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defectsComparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation featuresA Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutantCrystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific AcetylationThe molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatDThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseHuman Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL ANALYSIS USING TETRAPEPTIDE LIBRARY.Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.Towards a functional understanding of protein N-terminal acetylationSecretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting.Protein N-terminal acetyltransferases in cancer.NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum.N-acetylation and phosphorylation of Sec complex subunits in the ER membraneNew roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome.Experimental determination of the membrane topology of the Plasmodium protease Plasmepsin VMolecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrestDownregulation of N-terminal acetylation triggers ABA-mediated drought responses in ArabidopsisN-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.The N-terminal region of the Neurospora NDR kinase COT1 regulates morphology via its interactions with MOB2A/B.NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.
P2860
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P2860
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@ast
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@en
type
label
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@ast
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@en
prefLabel
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@ast
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@en
P2860
P1433
P1476
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum
@en
P2093
Colin J Stirling
Gabriella M A Forte
P2860
P304
P356
10.1371/JOURNAL.PBIO.1001073
P407
P577
2011-05-31T00:00:00Z